核糖核苷-二磷酸还原酶亚基 M2 在肺腺癌中的意义

IF 3.8 4区医学 Q2 GENETICS & HEREDITY

Current gene therapy Pub Date : 2024-06-12 DOI:10.2174/0115665232286359240611051307

Xiao-Jun Wang, Yun-Xia Huo, Peng-Jun Yang, Jing Gao, Weipeng Hu

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引用次数: 0

摘要

众所周知，核糖核苷-二磷酸还原酶亚基M2（RRM2）在多种癌症中过度表达，但其具体功能影响仍不清楚。本文旨在通过探讨RRM2在肺腺癌（LUAD）进展过程中的参与和潜在影响，阐明RRM2在肺腺癌中的作用。我们通过实验室实验评估了RRM2表达与免疫细胞浸润之间的关联，分析了其功能，并探讨了调节RRM2表达对LUAD细胞特征的影响。

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Significance of Ribonucleoside-diphosphate Reductase Subunit M2 in Lung Adenocarcinoma

The Ribonucleoside-diphosphate Reductase subunit M2 (RRM2) is known to be overexpressed in various cancers, though its specific functional implications remain unclear. This aims to elucidate the role of RRM2 in the progression of Lung Adenocarcinoma (LUAD) by exploring its involvement and potential impact. RRM2 data were sourced from multiple databases to assess its diagnostic and prognostic significance in LUAD. We evaluated the association between RRM2 expression and immune cell infiltration, analyzed its function, and explored the effects of modulating RRM2 expression on LUAD cell characteristics through laboratory experiments.

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来源期刊

Current gene therapy 医学-遗传学

CiteScore

6.70

自引率

2.80%

发文量

期刊介绍： Current Gene Therapy is a bi-monthly peer-reviewed journal aimed at academic and industrial scientists with an interest in major topics concerning basic research and clinical applications of gene and cell therapy of diseases. Cell therapy manuscripts can also include application in diseases when cells have been genetically modified. Current Gene Therapy publishes full-length/mini reviews and original research on the latest developments in gene transfer and gene expression analysis, vector development, cellular genetic engineering, animal models and human clinical applications of gene and cell therapy for the treatment of diseases. Current Gene Therapy publishes reviews and original research containing experimental data on gene and cell therapy. The journal also includes manuscripts on technological advances, ethical and regulatory considerations of gene and cell therapy. Reviews should provide the reader with a comprehensive assessment of any area of experimental biology applied to molecular medicine that is not only of significance within a particular field of gene therapy and cell therapy but also of interest to investigators in other fields. Authors are encouraged to provide their own assessment and vision for future advances. Reviews are also welcome on late breaking discoveries on which substantial literature has not yet been amassed. Such reviews provide a forum for sharply focused topics of recent experimental investigations in gene therapy primarily to make these results accessible to both clinical and basic researchers. Manuscripts containing experimental data should be original data, not previously published.