{"title":"评估颌面部硅胶中添加纳米氧化铜后对表皮葡萄球菌附着性的影响","authors":"Ahmed Jameel Mashloosh, Faiza M. Abdul-Ameer","doi":"10.36330/kmj.v20i1.14459","DOIUrl":null,"url":null,"abstract":"Background: Maxillofacial defects may arise from congenital, developmental, traumatic, or surgical procedures. The presence of such defects may adversely affect an individual's appearance and function, resulting in an inability to lead a typical life and impacting their psychological well-being. Surgical reconstruction is often regarded as the primary therapeutic option in such instances. However, it may not be feasible in numerous cases due to various unfavorable conditions. Consequently, the need for maxillofacial prosthesis reconstruction becomes obligatory. Purpose: This study assesses the antibacterial efficacy of copper oxide nanoparticles at different rates against Staphylococcus epidermidis after incorporation into maxillofacial silicone. Methods: A pilot study was first conducted in Iraq and copper oxide nanoparticles were added to VST50F silicone elastomer in different five percentages (0.01 wt%, 0.02 wt%, 0.03 wt%, 0.04 wt%, and 0.05 wt%). Thirty specimens were prepared and grouped into six groups: one control group and five experimental groups, and then the best effective two percentages (0.03 wt% and 0.04 wt%) were selected for the main study. Thirty specimens for the main study were divided into three groups: control group (A) and two experimental groups (B and C). A statistical analysis was done with an ANOVA and the Games-Howell multiple comparison test (P < 0.05). The data's normal distribution and homogeneity were assessed. Field emission scanning electron microscopy (FES-EM) and Fourier transform infrared spectroscopy (FTIR) were also conducted. Results: The statistical analysis showed a significant difference between all groups with P < 0.05. There was a significant difference between control group A and experimental groups B and C with P < 0.05, as well as between experimental groups B and C (P < 0.05). FESEM showed that nanoparticles were distributed well within the silicone matrix. FTIR spectra proved no chemical reaction to occurr between the copper oxide nanoparticles and VST50F silicone. Conclusion: Incorporating copper oxide nanoparticles into VST50F maxillofacial silicone improved their antibacterial efficacy against Staphylococcus epidermidis.","PeriodicalId":507092,"journal":{"name":"Kufa Medical Journal","volume":"9 12","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Evaluating the Effect of Copper Oxide Nanoparticles after Added to the Maxillofacial Silicone on the Adherence of Staphylococcus Epidermidis\",\"authors\":\"Ahmed Jameel Mashloosh, Faiza M. Abdul-Ameer\",\"doi\":\"10.36330/kmj.v20i1.14459\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background: Maxillofacial defects may arise from congenital, developmental, traumatic, or surgical procedures. The presence of such defects may adversely affect an individual's appearance and function, resulting in an inability to lead a typical life and impacting their psychological well-being. Surgical reconstruction is often regarded as the primary therapeutic option in such instances. However, it may not be feasible in numerous cases due to various unfavorable conditions. Consequently, the need for maxillofacial prosthesis reconstruction becomes obligatory. Purpose: This study assesses the antibacterial efficacy of copper oxide nanoparticles at different rates against Staphylococcus epidermidis after incorporation into maxillofacial silicone. Methods: A pilot study was first conducted in Iraq and copper oxide nanoparticles were added to VST50F silicone elastomer in different five percentages (0.01 wt%, 0.02 wt%, 0.03 wt%, 0.04 wt%, and 0.05 wt%). Thirty specimens were prepared and grouped into six groups: one control group and five experimental groups, and then the best effective two percentages (0.03 wt% and 0.04 wt%) were selected for the main study. Thirty specimens for the main study were divided into three groups: control group (A) and two experimental groups (B and C). A statistical analysis was done with an ANOVA and the Games-Howell multiple comparison test (P < 0.05). The data's normal distribution and homogeneity were assessed. Field emission scanning electron microscopy (FES-EM) and Fourier transform infrared spectroscopy (FTIR) were also conducted. Results: The statistical analysis showed a significant difference between all groups with P < 0.05. There was a significant difference between control group A and experimental groups B and C with P < 0.05, as well as between experimental groups B and C (P < 0.05). FESEM showed that nanoparticles were distributed well within the silicone matrix. FTIR spectra proved no chemical reaction to occurr between the copper oxide nanoparticles and VST50F silicone. Conclusion: Incorporating copper oxide nanoparticles into VST50F maxillofacial silicone improved their antibacterial efficacy against Staphylococcus epidermidis.\",\"PeriodicalId\":507092,\"journal\":{\"name\":\"Kufa Medical Journal\",\"volume\":\"9 12\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-06-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Kufa Medical Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.36330/kmj.v20i1.14459\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Kufa Medical Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.36330/kmj.v20i1.14459","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
背景:颌面部缺陷可能源于先天、发育、外伤或外科手术。这些缺陷的存在可能会对患者的外观和功能造成不利影响,导致其无法过正常生活,并影响其心理健康。在这种情况下,手术重建通常被视为主要的治疗方案。然而,在许多情况下,由于各种不利条件,手术可能并不可行。因此,必须进行颌面部假体重建。目的:本研究评估了氧化铜纳米颗粒加入颌面硅胶后对表皮葡萄球菌的不同抗菌率。研究方法:首先在伊拉克进行了一项试验性研究,在 VST50F 硅树脂弹性体中添加了不同比例的纳米氧化铜(0.01 wt%、0.02 wt%、0.03 wt%、0.04 wt% 和 0.05 wt%)。制备了 30 个试样并将其分为六组:一组对照组和五组实验组,然后选择效果最好的两个百分比(0.03 wt% 和 0.04 wt%)作为主要研究对象。主要研究的 30 个试样分为三组:对照组(A)和两个实验组(B 和 C)。统计分析采用方差分析和 Games-Howell 多重比较检验(P < 0.05)。对数据的正态分布和均匀性进行了评估。此外,还进行了场发射扫描电子显微镜(FES-EM)和傅立叶变换红外光谱(FTIR)分析。结果显示统计分析显示,各组间差异显著(P < 0.05)。对照组 A 与实验组 B 和 C 之间存在显著差异(P < 0.05),实验组 B 和 C 之间也存在显著差异(P < 0.05)。FESEM 显示,纳米颗粒在硅胶基质中分布良好。傅立叶变换红外光谱证明氧化铜纳米颗粒与 VST50F 硅胶之间没有发生化学反应。结论在 VST50F 颌面硅胶中加入纳米氧化铜颗粒可提高其对表皮葡萄球菌的抗菌效果。
Evaluating the Effect of Copper Oxide Nanoparticles after Added to the Maxillofacial Silicone on the Adherence of Staphylococcus Epidermidis
Background: Maxillofacial defects may arise from congenital, developmental, traumatic, or surgical procedures. The presence of such defects may adversely affect an individual's appearance and function, resulting in an inability to lead a typical life and impacting their psychological well-being. Surgical reconstruction is often regarded as the primary therapeutic option in such instances. However, it may not be feasible in numerous cases due to various unfavorable conditions. Consequently, the need for maxillofacial prosthesis reconstruction becomes obligatory. Purpose: This study assesses the antibacterial efficacy of copper oxide nanoparticles at different rates against Staphylococcus epidermidis after incorporation into maxillofacial silicone. Methods: A pilot study was first conducted in Iraq and copper oxide nanoparticles were added to VST50F silicone elastomer in different five percentages (0.01 wt%, 0.02 wt%, 0.03 wt%, 0.04 wt%, and 0.05 wt%). Thirty specimens were prepared and grouped into six groups: one control group and five experimental groups, and then the best effective two percentages (0.03 wt% and 0.04 wt%) were selected for the main study. Thirty specimens for the main study were divided into three groups: control group (A) and two experimental groups (B and C). A statistical analysis was done with an ANOVA and the Games-Howell multiple comparison test (P < 0.05). The data's normal distribution and homogeneity were assessed. Field emission scanning electron microscopy (FES-EM) and Fourier transform infrared spectroscopy (FTIR) were also conducted. Results: The statistical analysis showed a significant difference between all groups with P < 0.05. There was a significant difference between control group A and experimental groups B and C with P < 0.05, as well as between experimental groups B and C (P < 0.05). FESEM showed that nanoparticles were distributed well within the silicone matrix. FTIR spectra proved no chemical reaction to occurr between the copper oxide nanoparticles and VST50F silicone. Conclusion: Incorporating copper oxide nanoparticles into VST50F maxillofacial silicone improved their antibacterial efficacy against Staphylococcus epidermidis.