多种药用植物生化成分的血管舒张作用及其对糖尿病的益处

IF 4.2 3区医学 Q1 ENDOCRINOLOGY & METABOLISM

World Journal of Diabetes Pub Date : 2024-06-15 DOI:10.4239/wjd.v15.i6.1122

Sadettin Demirel

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引用次数: 0

摘要

内皮功能在心血管健康中起着举足轻重的作用，内皮功能失调会降低血管舒张功能和内皮活性。一氧化氮-环鸟苷-单磷酸途径、前列环素-环腺苷-单磷酸途径、磷酸二酯酶的抑制、钾通道的开放以及细胞内钙含量的降低，构成了调节血管舒张的关键机制。心血管疾病是导致糖尿病患者发病和死亡的重要因素，与非糖尿病患者相比，成年糖尿病患者的心血管风险更高。大量药用植物具有药理作用强、副作用小的特点，有望解决这些问题。在这篇综述中，我们介绍了多种药用植物及其各自的生化成分，展示了它们同时具有的舒张血管和抗糖尿病活性。

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Vasorelaxant effects of biochemical constituents of various medicinal plants and their benefits in diabetes

Endothelial function plays a pivotal role in cardiovascular health, and dysfunction in this context diminishes vasorelaxation concomitant with endothelial activity. The nitric oxide-cyclic guanosine monophosphate pathway, prostacyclin-cyclic adenosine monophosphate pathway, inhibition of phosphodiesterase, and the opening of potassium channels, coupled with the reduction of calcium levels in the cell, constitute critical mechanisms governing vasorelaxation. Cardiovascular disease stands as a significant contributor to morbidity and mortality among individuals with diabetes, with adults afflicted by diabetes exhibiting a heightened cardiovascular risk compared to their non-diabetic counterparts. A plethora of medicinal plants, characterized by potent pharmacological effects and minimal side effects, holds promise in addressing these concerns. In this review, we delineate various medicinal plants and their respective biochemical constituents, showcasing concurrent vasorelaxant and anti-diabetic activities.

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来源期刊

World Journal of Diabetes ENDOCRINOLOGY & METABOLISM-

自引率

2.40%

发文量

909

期刊介绍： The WJD is a high-quality, peer reviewed, open-access journal. The primary task of WJD is to rapidly publish high-quality original articles, reviews, editorials, and case reports in the field of diabetes. In order to promote productive academic communication, the peer review process for the WJD is transparent; to this end, all published manuscripts are accompanied by the anonymized reviewers’ comments as well as the authors’ responses. The primary aims of the WJD are to improve diagnostic, therapeutic and preventive modalities and the skills of clinicians and to guide clinical practice in diabetes. Scope: Diabetes Complications, Experimental Diabetes Mellitus, Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus, Diabetes, Gestational, Diabetic Angiopathies, Diabetic Cardiomyopathies, Diabetic Coma, Diabetic Ketoacidosis, Diabetic Nephropathies, Diabetic Neuropathies, Donohue Syndrome, Fetal Macrosomia, and Prediabetic State.