糖尿病肾病免疫紊乱的病理机制及干预策略

IF 4.2 3区医学 Q1 ENDOCRINOLOGY & METABOLISM

World Journal of Diabetes Pub Date : 2024-06-15 DOI:10.4239/wjd.v15.i6.1111

Tong Zhou, Yi-Lin Fang, Tian-Tian Tian, Gui-Xia Wang

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引用次数: 0

摘要

糖尿病肾病是糖尿病最严重的慢性微血管并发症之一，也是终末期肾病的主要病因。临床研究表明，肾脏炎症是决定糖尿病肾损害的关键因素。随着免疫学技术的发展，许多研究表明，糖尿病肾病是一种免疫复合物疾病，大多数患者存在免疫功能障碍。然而，糖尿病肾病与自身免疫性肾病、缺血或感染引起的急性肾损伤相关的免疫反应是不同的，具有复杂的病理机制。在这篇综述中，我们探讨了糖尿病肾病在免疫紊乱中的发病机制和干预机制，为糖尿病肾病的早期干预和治疗提供指导和建议。

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Pathological mechanism of immune disorders in diabetic kidney disease and intervention strategies

Diabetic kidney disease is one of the most severe chronic microvascular complications of diabetes and a primary cause of end-stage renal disease. Clinical studies have shown that renal inflammation is a key factor determining kidney damage during diabetes. With the development of immunological technology, many studies have shown that diabetic nephropathy is an immune complex disease, and that most patients have immune dysfunction. However, the immune response associated with diabetic nephropathy and autoimmune kidney disease, or caused by ischemia or infection with acute renal injury, is different, and has a com-plicated pathological mechanism. In this review, we discuss the pathogenesis of diabetic nephropathy in immune disorders and the intervention mechanism, to provide guidance and advice for early intervention and treatment of diabetic nephropathy.

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来源期刊

World Journal of Diabetes ENDOCRINOLOGY & METABOLISM-

自引率

2.40%

发文量

909

期刊介绍： The WJD is a high-quality, peer reviewed, open-access journal. The primary task of WJD is to rapidly publish high-quality original articles, reviews, editorials, and case reports in the field of diabetes. In order to promote productive academic communication, the peer review process for the WJD is transparent; to this end, all published manuscripts are accompanied by the anonymized reviewers’ comments as well as the authors’ responses. The primary aims of the WJD are to improve diagnostic, therapeutic and preventive modalities and the skills of clinicians and to guide clinical practice in diabetes. Scope: Diabetes Complications, Experimental Diabetes Mellitus, Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus, Diabetes, Gestational, Diabetic Angiopathies, Diabetic Cardiomyopathies, Diabetic Coma, Diabetic Ketoacidosis, Diabetic Nephropathies, Diabetic Neuropathies, Donohue Syndrome, Fetal Macrosomia, and Prediabetic State.