Saud Alenezi, Shorouk Dannoon, Naheel Alnafisi, Abdelhamid Elgazzar, Khaled Khalafalla
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Quantitative evaluation was performed on PET images using the total number of counts over the frontal bone and the ratio of counts between the frontal bone and iliac crest.</p><p><strong>Results: </strong>A total of 105 out of 249 cases were included in this study. Among these scans, there were 67 positive HFI in [ 18 F]NaF PET scans representing 64% of the studied population. As for the [ 18 F]NaF PET uptake pattern, there were 53 with uniformly diffused and 14 with heterogeneous uptake pattern. There were 17 out of 67 with positive HFI in [ 18 F]NaF PET scans but negative CT scans.</p><p><strong>Conclusion: </strong>HFI is a common finding on [ 18 F]NaF PET in obese patients and is probably underdiagnosed. HFI may present with a heterogeneous and diffuse pattern of uptake on [ 18 F]NaF PET. The proposed quantitative analysis using the count ratios is in agreement with the visual evaluation of [ 18 F]NaF PET images regardless of the CT findings. Awareness of this condition and its scintigraphic patterns is warranted since it can have clinical significance and may mimic other pathologies including metastasis in cancer patients.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":null,"pages":null},"PeriodicalIF":1.3000,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Hyperostosis frontalis interna on fluorine-18 sodium fluoride PET/computed tomography of obese cancer patients: a potential mimicker of metastasis.\",\"authors\":\"Saud Alenezi, Shorouk Dannoon, Naheel Alnafisi, Abdelhamid Elgazzar, Khaled Khalafalla\",\"doi\":\"10.1097/MNM.0000000000001873\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>The objective of this retrospective study was to identify the uptake patterns and suggest a quantitative method to detect hyperostosis frontalis interna (HFI) on fluorine-18 sodium fluoride ([ 18 F]NaF) PET/computed tomography (CT).</p><p><strong>Methods: </strong>Between January 2019 and December 2021, patients who underwent [ 18 F]NaF PET/CT with a BMI of 30 and above, were included. Three nuclear medicine consultants reviewed the studies to determine the presence and identify the uptake patterns of HFI. Quantitative evaluation was performed on PET images using the total number of counts over the frontal bone and the ratio of counts between the frontal bone and iliac crest.</p><p><strong>Results: </strong>A total of 105 out of 249 cases were included in this study. Among these scans, there were 67 positive HFI in [ 18 F]NaF PET scans representing 64% of the studied population. As for the [ 18 F]NaF PET uptake pattern, there were 53 with uniformly diffused and 14 with heterogeneous uptake pattern. There were 17 out of 67 with positive HFI in [ 18 F]NaF PET scans but negative CT scans.</p><p><strong>Conclusion: </strong>HFI is a common finding on [ 18 F]NaF PET in obese patients and is probably underdiagnosed. HFI may present with a heterogeneous and diffuse pattern of uptake on [ 18 F]NaF PET. The proposed quantitative analysis using the count ratios is in agreement with the visual evaluation of [ 18 F]NaF PET images regardless of the CT findings. Awareness of this condition and its scintigraphic patterns is warranted since it can have clinical significance and may mimic other pathologies including metastasis in cancer patients.</p>\",\"PeriodicalId\":19708,\"journal\":{\"name\":\"Nuclear Medicine Communications\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2024-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nuclear Medicine Communications\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1097/MNM.0000000000001873\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/6/14 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nuclear Medicine Communications","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/MNM.0000000000001873","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/6/14 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
引用次数: 0
摘要
研究目的这项回顾性研究旨在确定氟-18氟化钠（[18F]NaF）PET/计算机断层扫描（CT）的摄取模式，并提出一种定量方法来检测额肌间过度伸展症（HFI）：方法：纳入2019年1月至2021年12月期间接受[18F]NaF PET/CT检查的体重指数在30及以上的患者。三名核医学顾问对研究进行审查，以确定是否存在 HFI 并识别其摄取模式。利用额骨上的计数总数以及额骨和髂嵴之间的计数比对 PET 图像进行定量评估：结果：在 249 个病例中，共有 105 个病例被纳入本研究。在这些扫描中，[18F]NaF PET 扫描的 HFI 阳性有 67 例，占研究人数的 64%。在[18F]NaF PET 摄取模式方面，53 例为均匀弥散摄取，14 例为异质摄取。在 67 例[18F]NaF PET 扫描中，有 17 例 HFI 呈阳性，但 CT 扫描呈阴性：结论：HFI 是肥胖患者在[18F]NaF PET 扫描中的常见发现，但可能诊断不足。HFI 在[18F]NaF PET 上可能表现为异质性和弥漫性摄取模式。建议使用计数比进行定量分析，这与[18F]NaF PET 图像的目测评估结果一致，与 CT 结果无关。由于这种情况可能具有临床意义，并可能模拟其他病变，包括癌症患者的转移，因此有必要了解这种情况及其闪烁图形模式。
Hyperostosis frontalis interna on fluorine-18 sodium fluoride PET/computed tomography of obese cancer patients: a potential mimicker of metastasis.
Objective: The objective of this retrospective study was to identify the uptake patterns and suggest a quantitative method to detect hyperostosis frontalis interna (HFI) on fluorine-18 sodium fluoride ([ 18 F]NaF) PET/computed tomography (CT).
Methods: Between January 2019 and December 2021, patients who underwent [ 18 F]NaF PET/CT with a BMI of 30 and above, were included. Three nuclear medicine consultants reviewed the studies to determine the presence and identify the uptake patterns of HFI. Quantitative evaluation was performed on PET images using the total number of counts over the frontal bone and the ratio of counts between the frontal bone and iliac crest.
Results: A total of 105 out of 249 cases were included in this study. Among these scans, there were 67 positive HFI in [ 18 F]NaF PET scans representing 64% of the studied population. As for the [ 18 F]NaF PET uptake pattern, there were 53 with uniformly diffused and 14 with heterogeneous uptake pattern. There were 17 out of 67 with positive HFI in [ 18 F]NaF PET scans but negative CT scans.
Conclusion: HFI is a common finding on [ 18 F]NaF PET in obese patients and is probably underdiagnosed. HFI may present with a heterogeneous and diffuse pattern of uptake on [ 18 F]NaF PET. The proposed quantitative analysis using the count ratios is in agreement with the visual evaluation of [ 18 F]NaF PET images regardless of the CT findings. Awareness of this condition and its scintigraphic patterns is warranted since it can have clinical significance and may mimic other pathologies including metastasis in cancer patients.
期刊介绍：
Nuclear Medicine Communications, the official journal of the British Nuclear Medicine Society, is a rapid communications journal covering nuclear medicine and molecular imaging with radionuclides, and the basic supporting sciences. As well as clinical research and commentary, manuscripts describing research on preclinical and basic sciences (radiochemistry, radiopharmacy, radiobiology, radiopharmacology, medical physics, computing and engineering, and technical and nursing professions involved in delivering nuclear medicine services) are welcomed, as the journal is intended to be of interest internationally to all members of the many medical and non-medical disciplines involved in nuclear medicine. In addition to papers reporting original studies, frankly written editorials and topical reviews are a regular feature of the journal.
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