治疗诱导的衰老终于可以摆脱了,接下来该怎么办?

IF 3.4 3区 生物学 Q3 CELL BIOLOGY
Cell Cycle Pub Date : 2024-03-01 Epub Date: 2024-06-16 DOI:10.1080/15384101.2024.2364579
Tareq Saleh
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引用次数: 0

摘要

最近有几篇突破性的文章证实,肿瘤细胞有能力摆脱治疗诱导衰老(TIS)造成的稳定细胞周期停滞。因此,接受 TIS 是可以逃脱的这一假设,应鼓励人们认真重新评估衰老在癌症治疗中的基本作用。从 TIS 中逃脱的可能性破坏了衰老的肿瘤抑制功能,提出它是导致疾病复发的肿瘤休眠机制,并要求进一步研究它对癌症治疗结果的不利影响。此外,逃脱 TIS 强烈表明,主要通过药物手段消除衰老的肿瘤细胞是提高癌症治疗效果的合适方法,但这一方法仍需进一步探索。本评论综述了最近明确证明治疗诱导的衰老肿瘤细胞有能力克服生长停滞末期命运的证据,并对 TIS 在肿瘤生物学中的作用提供了未来展望。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Therapy-induced senescence is finally escapable, what is next?

Several breakthrough articles have recently confirmed the ability of tumor cells to escape the stable cell cycle arrest imposed by Therapy-Induced Senescence (TIS). Subsequently, accepting the hypothesis that TIS is escapable should encourage serious reassessments of the fundamental roles of senescence in cancer treatment. The potential for escape from TIS undermines the well-established tumor suppressor function of senescence, proposes it as a mechanism of tumor dormancy leading to disease recurrence and invites for further investigation of its unfavorable contribution to cancer therapy outcomes. Moreover, escaping TIS strongly indicates that the elimination of senescent tumor cells, primarily through pharmacological means, is a suitable approach for increasing the efficacy of cancer treatment, one that still requires further exploration. This commentary provides an overview of the recent evidence that unequivocally demonstrated the ability of therapy-induced senescent tumor cells in overcoming the terminal growth arrest fate and provides future perspectives on the roles of TIS in tumor biology.

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来源期刊
Cell Cycle
Cell Cycle 生物-细胞生物学
CiteScore
7.70
自引率
2.30%
发文量
281
审稿时长
1 months
期刊介绍: Cell Cycle is a bi-weekly peer-reviewed journal of high priority research from all areas of cell biology. Cell Cycle covers all topics from yeast to man, from DNA to function, from development to aging, from stem cells to cell senescence, from metabolism to cell death, from cancer to neurobiology, from molecular biology to therapeutics. Our goal is fast publication of outstanding research.
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