气体递质和惰性气体在心脏保护中的作用:揭示未来治疗策略的分子途径。

IF 7.5 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS
Basic Research in Cardiology Pub Date : 2024-08-01 Epub Date: 2024-06-15 DOI:10.1007/s00395-024-01061-1
Pasquale Pagliaro, Nina C Weber, Saveria Femminò, Giuseppe Alloatti, Claudia Penna
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引用次数: 0

摘要

尽管近来取得了一些进展,但缺血性心脏病仍是一个持续存在的全球性挑战,导致了严重的发病率和死亡率。为了寻求治疗方案,出现了缺血预处理、后处理和远程调节等策略,以保护心脏免受心肌缺血/再灌注损伤(MIRI)。这些缺血调理方法可在受影响器官之前、之后或远离受影响器官的地方使用,为未来的治疗策略(包括药理调理)提供了灵感。气体递质包括一氧化氮、硫化氢、二氧化硫和一氧化碳,在生理和病理过程中发挥着关键作用,具有平滑肌松弛、抗凋亡作用和抗炎特性等共同特征。尽管高浓度气体存在潜在风险,但生理水平的气体递质可诱导血管舒张并促进心脏保护作用。惰性气体,尤其是氩气、氦气和氙气,通过减少细胞死亡、缩小梗塞面积和增强缺血后器官的功能恢复,表现出器官保护特性。惰性气体的保护作用似乎取决于它们对细胞存活分子途径的调节,从而产生促凋亡和抗凋亡作用。在惰性气体中,氦气和氙气在心脏保护领域尤其具有前景。本文综述了我们目前对气体递质和惰性气体在 MIRI 和心脏保护方面所起作用的理解。此外,我们还强调了利用惰性气体和气体递质供体分子推进心脏保护策略的未来发展潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Gasotransmitters and noble gases in cardioprotection: unraveling molecular pathways for future therapeutic strategies.

Gasotransmitters and noble gases in cardioprotection: unraveling molecular pathways for future therapeutic strategies.

Despite recent progress, ischemic heart disease poses a persistent global challenge, driving significant morbidity and mortality. The pursuit of therapeutic solutions has led to the emergence of strategies such as ischemic preconditioning, postconditioning, and remote conditioning to shield the heart from myocardial ischemia/reperfusion injury (MIRI). These ischemic conditioning approaches, applied before, after, or at a distance from the affected organ, inspire future therapeutic strategies, including pharmacological conditioning. Gasotransmitters, comprising nitric oxide, hydrogen sulfide, sulfur dioxide, and carbon monoxide, play pivotal roles in physiological and pathological processes, exhibiting shared features such as smooth muscle relaxation, antiapoptotic effects, and anti-inflammatory properties. Despite potential risks at high concentrations, physiological levels of gasotransmitters induce vasorelaxation and promote cardioprotective effects. Noble gases, notably argon, helium, and xenon, exhibit organ-protective properties by reducing cell death, minimizing infarct size, and enhancing functional recovery in post-ischemic organs. The protective role of noble gases appears to hinge on their modulation of molecular pathways governing cell survival, leading to both pro- and antiapoptotic effects. Among noble gases, helium and xenon emerge as particularly promising in the field of cardioprotection. This overview synthesizes our current understanding of the roles played by gasotransmitters and noble gases in the context of MIRI and cardioprotection. In addition, we underscore potential future developments involving the utilization of noble gases and gasotransmitter donor molecules in advancing cardioprotective strategies.

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来源期刊
Basic Research in Cardiology
Basic Research in Cardiology 医学-心血管系统
CiteScore
16.30
自引率
5.30%
发文量
54
审稿时长
6-12 weeks
期刊介绍: Basic Research in Cardiology is an international journal for cardiovascular research. It provides a forum for original and review articles related to experimental cardiology that meet its stringent scientific standards. Basic Research in Cardiology regularly receives articles from the fields of - Molecular and Cellular Biology - Biochemistry - Biophysics - Pharmacology - Physiology and Pathology - Clinical Cardiology
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