在一项全球多中心研究(2020-2022 年)中,氧佐沙星对金黄色葡萄球菌和化脓性链球菌临床分离物的体外活性。

IF 3.7 Q2 INFECTIOUS DISEASES
JAC-Antimicrobial Resistance Pub Date : 2024-06-13 eCollection Date: 2024-06-01 DOI:10.1093/jacamr/dlae088
María García-Castillo, Marta Hernández-García, Adriana Correa, Marco Coppi, Thomas Griener, Thomas Fritsche, Cristina Pitart, Jorge Sampaio, Harald Seifert, Karen Wake, Mandy Wootton, Jordi Vila, Rafael Cantón
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Results were interpreted following European Committee on Antimicrobial Susceptibility Testing (EUCAST) 2023 (clinical breakpoints, ECOFF) and CLSI criteria.</p><p><strong>Results: </strong>Ozenoxacin exhibited high <i>in vitro</i> activity against <i>S. aureus</i> (MIC<sub>50/90</sub> = 0.002/0.12 mg/L) and <i>S. pyogenes</i> (MIC<sub>50/90</sub> = 0.015/0.03 mg/L), inhibiting 99% of the isolates at MIC ≤ 0.5 mg/L and at MIC ≤ 0.06, respectively. The most active comparators against <i>S. aureus</i> were retapamulin (MIC<sub>90</sub> = 0.12 mg/L), fusidic acid (MIC<sub>90</sub> = 0.25 mg/L) and mupirocin (MIC<sub>90</sub> = 0.5 mg/L); and against <i>S. pyogenes</i> were retapamulin (MIC<sub>90</sub> = 0.03 mg/L), clindamycin (MIC<sub>90</sub> = 0.12 mg/L) and mupirocin (MIC<sub>90</sub> = 0.25 mg/L). Ciprofloxacin and methicillin resistant rates for <i>S. aureus</i> were 31.3% (455/1454) and 41% (598/1454), respectively. 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引用次数: 0

摘要

研究目的我们开展了一项多中心研究(2020-2022 年),比较氧佐沙星和比较药物对皮肤和软组织感染(SSTI)中金黄色葡萄球菌和化脓性链球菌临床分离株的体外活性:2020年1月至2022年12月期间,在8个国家的10个中心共收集了1725株分离株(1454株金黄色葡萄球菌和271株化脓性链球菌)。抗菌药敏感性测试(微量稀释-SENSITITRE)。结果按照欧洲抗菌药物敏感性检测委员会(EUCAST)2023(临床断点、ECOFF)和 CLSI 标准进行解释:结果:奥唑沙星对金黄色葡萄球菌(MIC50/90=0.002/0.12 mg/L)和化脓性葡萄球菌(MIC50/90=0.015/0.03 mg/L)具有很高的体外活性,在MIC≤0.5 mg/L和MIC≤0.06时分别抑制99%的分离株。对金黄色葡萄球菌最有效的比较药是雷他霉素(MIC90 = 0.12 mg/L)、夫西地酸(MIC90 = 0.25 mg/L)和莫匹罗星(MIC90 = 0.5 mg/L);对化脓性葡萄球菌最有效的比较药是雷他霉素(MIC90 = 0.03 mg/L)、克林霉素(MIC90 = 0.12 mg/L)和莫匹罗星(MIC90 = 0.25 mg/L)。金黄色葡萄球菌对环丙沙星和甲氧西林的耐药率分别为 31.3%(455/1454)和 41%(598/1454)。此外,62%(373/598)的 MRSA 也对环丙沙星不敏感,而只有 10% (23/271)的 MSSA 对环丙沙星耐药。氧佐沙星对环丙沙星敏感的金黄色葡萄球菌的活性高于对环丙沙星耐药的分离株,对 MRSA 分离株的 MIC 值略高于对 MSSA 的 MIC 值。不过,氧烯诺沙星在耐环丙沙星的 MSSA 和 MRSA 亚群中的活性相当。另一方面,氧佐沙星在对环丙沙星敏感和耐药的化脓性链球菌分离物中具有相似的活性:结论:奥泽诺沙星是一种有效的抗菌剂,可用于抗击引起 SSTI 的革兰氏阳性细菌,包括对环丙沙星不敏感的 MRSA 分离物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
In vitro activity of ozenoxacin against Staphylococcus aureus and Streptococcus pyogenes clinical isolates recovered in a worldwide multicentre study (2020-2022).

Objectives: We performed a multicentre study (2020-2022) to compare the in vitro activity of ozenoxacin and comparator agents against Staphylococcus aureus and Streptococcus pyogenes clinical isolates from skin and soft-tissue infections (SSTI).

Methods: A total of 1725 isolates (1454 S. aureus and 271 S. pyogenes) were collected in 10 centres from eight countries between January 2020 and December 2022. Antimicrobial susceptibility testing was determined (microdilution-SENSITITRE). Results were interpreted following European Committee on Antimicrobial Susceptibility Testing (EUCAST) 2023 (clinical breakpoints, ECOFF) and CLSI criteria.

Results: Ozenoxacin exhibited high in vitro activity against S. aureus (MIC50/90 = 0.002/0.12 mg/L) and S. pyogenes (MIC50/90 = 0.015/0.03 mg/L), inhibiting 99% of the isolates at MIC ≤ 0.5 mg/L and at MIC ≤ 0.06, respectively. The most active comparators against S. aureus were retapamulin (MIC90 = 0.12 mg/L), fusidic acid (MIC90 = 0.25 mg/L) and mupirocin (MIC90 = 0.5 mg/L); and against S. pyogenes were retapamulin (MIC90 = 0.03 mg/L), clindamycin (MIC90 = 0.12 mg/L) and mupirocin (MIC90 = 0.25 mg/L). Ciprofloxacin and methicillin resistant rates for S. aureus were 31.3% (455/1454) and 41% (598/1454), respectively. Additionally, 62% (373/598) of the MRSA were also ciprofloxacin non-susceptible, whereas only 10% (23/271) of the MSSA were ciprofloxacin resistant. Ozenoxacin was more active against ciprofloxacin-susceptible S. aureus than against ciprofloxacin-resistant isolates, and showed a slightly higher MIC in MRSA isolates than in MSSA. However, ozenoxacin activity was comparable in both ciprofloxacin-resistant MSSA and MRSA subsets. On the other hand, ozenoxacin had similar activity in ciprofloxacin-susceptible and resistant S. pyogenes isolates.

Conclusions: Ozenoxacin is a potent antimicrobial agent of topic use against Gram-positive bacteria causing SSTI, including MRSA isolates non-susceptible to ciprofloxacin.

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