转移部位的细菌：揭开癌症发展过程中隐藏的角色

IF 48.8 1区医学 Q1 CELL BIOLOGY

Cancer Cell Pub Date : 2024-06-13 DOI:10.1016/j.ccell.2024.05.022

Philippe Stevens, Elena Benidovskaya, Veronica Llorens-Rico, Jeroen Raes, Marc Van Den Eynde

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引用次数: 0

摘要

细菌表现出癌症转移的关键特征，如运动性、侵袭性和对肿瘤微环境的调节。它们通过淋巴和血液系统迁移，侵入转移组织，并改变局部微环境以支持转移生长。细菌还能塑造肿瘤微环境，影响免疫反应和炎症，从而影响肿瘤进展和治疗反应。虽然细菌具有治疗潜力，但污染和复杂的特征描述等挑战依然存在，因此有必要进行先进的测序和临床应用研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Bacteria in metastatic sites: Unveiling hidden players in cancer progression

Bacteria exhibit key features of cancer metastasis, such as motility, invasion, and modulation of the tumor microenvironment. They migrate through lymphatic and blood systems, invade metastatic tissues, and alter local microenvironments to support metastatic growth. Bacteria also shape the tumor microenvironment, affecting immune responses and inflammation, which influence tumor progression and therapy response. While they hold therapeutic potential, challenges like contamination and complex characterization persist, necessitating advanced sequencing and research for clinical application.

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来源期刊

Cancer Cell 医学-肿瘤学

CiteScore

55.20

自引率

1.20%

发文量

179

审稿时长

4-8 weeks

期刊介绍： Cancer Cell is a journal that focuses on promoting major advances in cancer research and oncology. The primary criteria for considering manuscripts are as follows: Major advances: Manuscripts should provide significant advancements in answering important questions related to naturally occurring cancers. Translational research: The journal welcomes translational research, which involves the application of basic scientific findings to human health and clinical practice. Clinical investigations: Cancer Cell is interested in publishing clinical investigations that contribute to establishing new paradigms in the treatment, diagnosis, or prevention of cancers. Insights into cancer biology: The journal values clinical investigations that provide important insights into cancer biology beyond what has been revealed by preclinical studies. Mechanism-based proof-of-principle studies: Cancer Cell encourages the publication of mechanism-based proof-of-principle clinical studies, which demonstrate the feasibility of a specific therapeutic approach or diagnostic test.