全基因组关联研究中隐私增强技术的法律问题及其对绩效和可行性的影响

IF 10.1 1区生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Genome Biology Pub Date : 2024-06-13 DOI:10.1186/s13059-024-03296-6

Alissa Brauneck, Louisa Schmalhorst, Stefan Weiss, Linda Baumbach, Uwe Völker, David Ellinghaus, Jan Baumbach, Gabriele Buchholtz

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引用次数: 0

摘要

基因组数据为医学进步带来巨大潜力，但由于其敏感性，需要严格的安全措施来遵守数据保护法。这种冲突在全基因组关联研究（GWAS）中尤为明显，因为该研究依赖大量基因组数据来改进医疗诊断。为了确保研究的益处和足够的数据安全，我们提出了一种结合隐私增强技术的联合方法，利用关于联合学习和一般法律法规的系统综述中的发现，并将其应用于全基因组关联研究。

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Legal aspects of privacy-enhancing technologies in genome-wide association studies and their impact on performance and feasibility

Genomic data holds huge potential for medical progress but requires strict safety measures due to its sensitive nature to comply with data protection laws. This conflict is especially pronounced in genome-wide association studies (GWAS) which rely on vast amounts of genomic data to improve medical diagnoses. To ensure both their benefits and sufficient data security, we propose a federated approach in combination with privacy-enhancing technologies utilising the findings from a systematic review on federated learning and legal regulations in general and applying these to GWAS.

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来源期刊

Genome Biology Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

21.00

自引率

3.30%

发文量

241

审稿时长

2 months

期刊介绍： Genome Biology stands as a premier platform for exceptional research across all domains of biology and biomedicine, explored through a genomic and post-genomic lens. With an impressive impact factor of 12.3 (2022),* the journal secures its position as the 3rd-ranked research journal in the Genetics and Heredity category and the 2nd-ranked research journal in the Biotechnology and Applied Microbiology category by Thomson Reuters. Notably, Genome Biology holds the distinction of being the highest-ranked open-access journal in this category. Our dedicated team of highly trained in-house Editors collaborates closely with our esteemed Editorial Board of international experts, ensuring the journal remains on the forefront of scientific advances and community standards. Regular engagement with researchers at conferences and institute visits underscores our commitment to staying abreast of the latest developments in the field.