感染幽门螺杆菌的慢性胃炎、肠型胃癌和家族性胃癌患者的基因突变。

IF 2 4区医学 Q3 ONCOLOGY

Hereditary Cancer in Clinical Practice Pub Date : 2024-06-12 DOI:10.1186/s13053-024-00282-8

Andrzej Hnatyszyn, Marlena Szalata, Aleksandra Zielińska, Karolina Wielgus, Mikołaj Danielewski, Piotr Tomasz Hnatyszyn, Andrzej Pławski, Jarosław Walkowiak, Ryszard Słomski

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引用次数: 0

摘要

背景：导致胃癌的粘液序列变化和家族性肠型胃癌病例的发生与幽门螺杆菌感染有广泛联系。在这项研究中，我们分析了幽门螺杆菌感染者肠道中涉及癌症发生和炎症过程的基因变异。我们的目的是检测这些基因的突变是否会导致胃癌的发生，以及是否有遗传因素使幽门螺杆菌感染更有可能导致胃癌。由于幽门螺杆菌感染比较常见，发现这种遗传倾向可用于建立风险群体和制定治疗计划：我们的研究涵盖了对癌症发生相关基因变异的分析：方法：我们的研究涵盖了与癌症发生有关的基因变异分析：TP53（rs11540652、rs587782329、COSM10771）、MSH2（rs193922376）、MLH1（rs63750217），以及肠道炎症过程：结果发现，幽门螺杆菌感染患者的NOD2（rs2066847、rs2066842）、IL1A（rs1800587）和IL1B（rs1143634）基因突变更常见：与慢性胃炎、慢性萎缩性胃炎、肠化生、发育不良或胃癌患者相比，肠型胃癌和家族性胃癌患者中的突变更为常见（p值=0.00824），家族性胃癌患者与其他粘膜病变患者相比，p53突变的发生率更高（p值=0.000049）。此外，胃癌患者的 NOD2 基因 rs2066842 变体的基因型主要为 TT 或 CT：结论：参与炎症过程的其他白细胞介素基因未发生有统计学意义的变化，这可能表明幽门螺杆菌感染是胃黏膜炎症过程发展的潜在诱因，并通过微生物群失调导致肠胃癌的发生。所分析基因的突变与更严重的粘膜变化相关，TP53 基因突变更为常见，而其他基因突变在胃癌家族史中出现的频率有限。

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Mutations in Helicobacter pylori infected patients with chronic gastritis, intestinal type of gastric cancer and familial gastric cancer.

Background: Development of sequential changes of mucous leading to gastric cancer and familial cases of gastric cancer of intestinal type is widely connected with Helicobacter pylori infections. In this study we analysed variants of genes involved in cancerogenesis and inflammatory processes of intestines in patients infected with H.pylori. Our goal was to test whether mutations in these genes predestinate to development of gastric cancer, and whether there is a genetic factor that makes it more likely for infections with H.pylori to cause gastric cancer. As infections with H. pylori are relatively common, discovering such genetic predispositions could be used for establishing risk-groups and for planning treatments.

Methods: Our studies cover analysis of variants in genes involved in cancerogenesis: TP53 (rs11540652, rs587782329, COSM10771), MSH2 (rs193922376), MLH1 (rs63750217), and inflammatory processes of intestine: NOD2 (rs2066847, rs2066842), IL1A (rs1800587) and IL1B (rs1143634) from H.pylori-infected patients.

Results: Mutations were more common in the group of patients with gastric cancer of intestinal type and familial cases of gastric cancer in comparison with patients with chronic gastritis, chronic atrophic gastritis, intestinal metaplasia, dysplasia or gastric cancer (p-value = 0.00824), with the prevalence of p53 mutations in patients with familial gastric cancer vs. patients with other changes of mucosa (p-value = 0.000049). Additionally, gastric cancer patients have mainly genotype TT or CT of the rs2066842 variant of the NOD2 gene.

Conclusions: The lack of statistically significant changes of other interleukin genes involved in inflammatory processes may suggest the presence of H.pylori infection as a potential trigger for the development of the inflammatory process of the mucosa, leading through microbiota dysbiosis to the development of enteric gastric cancer. Mutations in analysed genes correlated with more severe mucosal changes, with a much more frequent presence of TP53 gene mutations, with a limited presence of other mutations in the familial history of gastric cancer.

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来源期刊

Hereditary Cancer in Clinical Practice 医学-肿瘤学

CiteScore

3.10

自引率

5.90%

发文量

审稿时长

>12 weeks

期刊介绍： Hereditary Cancer in Clinical Practice is an open access journal that publishes articles of interest for the cancer genetics community and serves as a discussion forum for the development appropriate healthcare strategies. Cancer genetics encompasses a wide variety of disciplines and knowledge in the field is rapidly growing, especially as the amount of information linking genetic differences to inherited cancer predispositions continues expanding. With the increased knowledge of genetic variability and how this relates to cancer risk there is a growing demand not only to disseminate this information into clinical practice but also to enable competent debate concerning how such information is managed and what it implies for patient care. Topics covered by the journal include but are not limited to: Original research articles on any aspect of inherited predispositions to cancer. Reviews of inherited cancer predispositions. Application of molecular and cytogenetic analysis to clinical decision making. Clinical aspects of the management of hereditary cancers. Genetic counselling issues associated with cancer genetics. The role of registries in improving health care of patients with an inherited predisposition to cancer.