Jose Nativi-Nicolau, Ali Yilmaz, Noel Dasgupta, Richard Macey, James Cochrane, Judith Peatman, Catherine Summers, Jennifer Luth, Ronald Zolty
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引用次数: 0
摘要
目的：六分钟步行测试（6MWT）是衡量心力衰竭（HF）患者功能能力的常用方法。心肌病（CM）试验（包括转甲状腺素介导的淀粉样变性伴心肌病（ATTR-CM））的主要临床研究终点通常仅限于住院时间和死亡率。研究目的研究 6MWT 与包括 ATTR-CM 在内的 CM 住院率或死亡率之间的关系。方法：使用 CM、6MWT、住院和死亡率等检索词进行 PRISMA 指导下的系统性文献综述。结果：共发现 41 项研究报告了 CM 患者的 6MWT 数据和住院或死亡率数据。数据表明，6MWT 距离越大，CM 患者住院或死亡风险越低。结论：6MWT 是包括 ATTR-CM 在内的 CM 试验中公认的替代终点。
Six-minute walk test as clinical end point in cardiomyopathy clinical trials, including ATTR-CM: a systematic literature review.
Aim: The six-minute walk test (6MWT) is a common measure of functional capacity in patients with heart failure (HF). Primary clinical study end points in cardiomyopathy (CM) trials, including transthyretin-mediated amyloidosis with CM (ATTR-CM), are often limited to hospitalization and mortality. Objective: To investigate the relationship between the 6MWT and hospitalization or mortality in CM, including ATTR-CM. Method: A PRISMA-guided systematic literature review was conducted using search terms for CM, 6MWT, hospitalization and mortality. Results: Forty-one studies were identified that reported 6MWT data and hospitalization or mortality data for patients with CM. The data suggest that a greater 6MWT distance is associated with a reduced risk of hospitalization or mortality in CM. Conclusion: The 6MWT is an accepted alternative end point in CM trials, including ATTR-CM.
期刊介绍：
Journal of Comparative Effectiveness Research provides a rapid-publication platform for debate, and for the presentation of new findings and research methodologies.
Through rigorous evaluation and comprehensive coverage, the Journal of Comparative Effectiveness Research provides stakeholders (including patients, clinicians, healthcare purchasers, and health policy makers) with the key data and opinions to make informed and specific decisions on clinical practice.
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