Ana Martínez-Riaño, Laura Mosteo, Paula Molero-Glez, Iván Márquez-Rodas, Ignacio Melero
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引用次数: 0
摘要
病毒感染分子的存在对于通过 Toll 样受体 3 (TLR3) 等先天受体产生强大的细胞毒性 T 细胞免疫反应至关重要。在癌症免疫疗法方面,有几种安全的病毒双链 RNA(dsRNA)类似物在小鼠模型中的疗效令人信服,目前正在进行临床开发。
Double-Stranded RNA to Mimic Viral Infection for Cancer Immunotherapy.
The presence of moieties denoting viral infection is crucial to mount powerful cytotoxic T-cell immune responses acting through innate receptors such as Toll-like receptor 3. For cancer immunotherapy, several safe analogues of viral double-stranded RNA are under clinical development following compelling evidence for efficacy in mouse models. See related article by van Eijck et al., p. 3447.
期刊介绍:
Clinical Cancer Research is a journal focusing on groundbreaking research in cancer, specifically in the areas where the laboratory and the clinic intersect. Our primary interest lies in clinical trials that investigate novel treatments, accompanied by research on pharmacology, molecular alterations, and biomarkers that can predict response or resistance to these treatments. Furthermore, we prioritize laboratory and animal studies that explore new drugs and targeted agents with the potential to advance to clinical trials. We also encourage research on targetable mechanisms of cancer development, progression, and metastasis.