Robert G Memelink, Aveline Hijlkema, Bas Valentin, Martinet T Streppel, Wilrike J Pasman, Suzan Wopereis, Johan de Vogel-van den Bosch, Michael Tieland, Josje D Schoufour, Ivan Bautmans, Peter JM Weijs
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This study aimed to evaluate the long-term effect of a 3-month lifestyle intervention, with or without supplementation of a protein drink, to preserve lean mass in older adults with obesity and type 2 diabetes at 6 months post-intervention.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>Adults (<i>n</i> = 123) aged ≥55 years with obesity and type 2 diabetes were enrolled in a 3-month intensive lifestyle intervention including a hypocaloric diet, resistance exercise and high-intensity interval training. Participants were randomized to either receive a leucine and vitamin D-enriched protein drink or an isocaloric control drink. The 3-month intervention was followed by a 6-month phase without intervention. At baseline, 3 and 9 months (follow-up) body composition, physical functioning, physical activity and quality of life were assessed. Statistical analyses were performed using linear mixed models.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Body weight loss was largely sustained at follow-up (−2.1 kg compared to baseline, 95% CI [−2.8, −1.5]) and comprised a sustained loss of fat mass (−2.6 kg, 95% CI [−3.2, −2.0]) with a simultaneous gain of lean mass (+0.7 kg, 95% CI [+0.2, +1.2]). Improvements in 400 m walk speed (+0.05 m/s, 95% CI [+0.03, +0.08]) and chair stand test time (−1.5 s, 95% CI [−1.9, −1.1]) were sustained at follow-up. There were no differences in these changes between the protein supplementation group and the control group at follow-up.</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>Older adults with obesity and type 2 diabetes preserved their lean mass, their loss of fat mass and their improvements in physical functioning at 6 months post-intervention. Protein supplementation during intervention did not affect outcomes at follow-up.</p>\n </section>\n </div>","PeriodicalId":74076,"journal":{"name":"Lifestyle medicine (Hoboken, N.J.)","volume":"5 3","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/lim2.103","citationCount":"0","resultStr":"{\"title\":\"Long-term preservation of lean mass and sustained loss of fat mass after completion of an intensive lifestyle intervention in older adults with obesity and type 2 diabetes\",\"authors\":\"Robert G Memelink, Aveline Hijlkema, Bas Valentin, Martinet T Streppel, Wilrike J Pasman, Suzan Wopereis, Johan de Vogel-van den Bosch, Michael Tieland, Josje D Schoufour, Ivan Bautmans, Peter JM Weijs\",\"doi\":\"10.1002/lim2.103\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Introduction</h3>\\n \\n <p>Lifestyle interventions combining caloric restriction with resistance exercise have the potential to preserve lean mass during weight loss. Additional protein intake can further improve lean mass. However, it is unclear whether these effects are sustained after completion of the intervention. This study aimed to evaluate the long-term effect of a 3-month lifestyle intervention, with or without supplementation of a protein drink, to preserve lean mass in older adults with obesity and type 2 diabetes at 6 months post-intervention.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>Adults (<i>n</i> = 123) aged ≥55 years with obesity and type 2 diabetes were enrolled in a 3-month intensive lifestyle intervention including a hypocaloric diet, resistance exercise and high-intensity interval training. Participants were randomized to either receive a leucine and vitamin D-enriched protein drink or an isocaloric control drink. The 3-month intervention was followed by a 6-month phase without intervention. 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引用次数: 0
摘要
导言 结合热量限制和阻力运动的生活方式干预措施有可能在减肥期间保持瘦体重。额外摄入蛋白质可进一步提高瘦体重。然而，目前还不清楚这些效果在干预结束后是否会持续。本研究旨在评估为期 3 个月的生活方式干预（无论是否补充蛋白质饮料）对肥胖和 2 型糖尿病老年人在干预后 6 个月保持瘦体重的长期效果。 方法 年龄≥55 岁的肥胖和 2 型糖尿病成人（n = 123）参加为期 3 个月的强化生活方式干预，包括低热量饮食、阻力运动和高强度间歇训练。参与者被随机分配到一种富含亮氨酸和维生素 D 的蛋白质饮料或一种等热量的对照饮料中。在为期 3 个月的干预之后是为期 6 个月的无干预阶段。在基线、3 个月和 9 个月（随访）期间，对身体成分、身体机能、体力活动和生活质量进行了评估。采用线性混合模型进行统计分析。 结果 随访期间，体重下降基本保持不变（与基线相比，体重下降 2.1 千克，95% CI [-2.8, -1.5]），其中脂肪含量持续下降（-2.6 千克，95% CI [-3.2, -2.0]），同时瘦肉含量增加（+0.7 千克，95% CI [+0.2, +1.2]）。400 米步行速度（+0.05 米/秒，95% CI [+0.03，+0.08]）和椅子站立测试时间（-1.5 秒，95% CI [-1.9，-1.1]）的改善在随访中得以持续。在随访期间，补充蛋白质组与对照组在这些变化上没有差异。 结论 患有肥胖症和 2 型糖尿病的老年人在干预后 6 个月仍能保持其瘦肉含量、脂肪含量和身体机能的改善。干预期间补充蛋白质不会影响随访结果。
Long-term preservation of lean mass and sustained loss of fat mass after completion of an intensive lifestyle intervention in older adults with obesity and type 2 diabetes
Introduction
Lifestyle interventions combining caloric restriction with resistance exercise have the potential to preserve lean mass during weight loss. Additional protein intake can further improve lean mass. However, it is unclear whether these effects are sustained after completion of the intervention. This study aimed to evaluate the long-term effect of a 3-month lifestyle intervention, with or without supplementation of a protein drink, to preserve lean mass in older adults with obesity and type 2 diabetes at 6 months post-intervention.
Methods
Adults (n = 123) aged ≥55 years with obesity and type 2 diabetes were enrolled in a 3-month intensive lifestyle intervention including a hypocaloric diet, resistance exercise and high-intensity interval training. Participants were randomized to either receive a leucine and vitamin D-enriched protein drink or an isocaloric control drink. The 3-month intervention was followed by a 6-month phase without intervention. At baseline, 3 and 9 months (follow-up) body composition, physical functioning, physical activity and quality of life were assessed. Statistical analyses were performed using linear mixed models.
Results
Body weight loss was largely sustained at follow-up (−2.1 kg compared to baseline, 95% CI [−2.8, −1.5]) and comprised a sustained loss of fat mass (−2.6 kg, 95% CI [−3.2, −2.0]) with a simultaneous gain of lean mass (+0.7 kg, 95% CI [+0.2, +1.2]). Improvements in 400 m walk speed (+0.05 m/s, 95% CI [+0.03, +0.08]) and chair stand test time (−1.5 s, 95% CI [−1.9, −1.1]) were sustained at follow-up. There were no differences in these changes between the protein supplementation group and the control group at follow-up.
Conclusions
Older adults with obesity and type 2 diabetes preserved their lean mass, their loss of fat mass and their improvements in physical functioning at 6 months post-intervention. Protein supplementation during intervention did not affect outcomes at follow-up.
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