{"title":"RNase P：超越前体 tRNA 处理。","authors":"Peipei Wang, Juntao Lin, Xiangyang Zheng, Xingzhi Xu","doi":"10.1093/gpbjnl/qzae016","DOIUrl":null,"url":null,"abstract":"<p><p>Ribonuclease P (RNase P) was first described in the 1970's as an endoribonuclease acting in the maturation of precursor transfer RNAs (tRNAs). More recent studies, however, have uncovered non-canonical roles for RNase P and its components. Here, we review the recent progress of its involvement in chromatin assembly, DNA damage response, and maintenance of genome stability with implications in tumorigenesis. The possibility of RNase P as a therapeutic target in cancer is also discussed.</p>","PeriodicalId":94020,"journal":{"name":"Genomics, proteomics & bioinformatics","volume":"22 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"RNase P: Beyond Precursor tRNA Processing.\",\"authors\":\"Peipei Wang, Juntao Lin, Xiangyang Zheng, Xingzhi Xu\",\"doi\":\"10.1093/gpbjnl/qzae016\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Ribonuclease P (RNase P) was first described in the 1970's as an endoribonuclease acting in the maturation of precursor transfer RNAs (tRNAs). More recent studies, however, have uncovered non-canonical roles for RNase P and its components. Here, we review the recent progress of its involvement in chromatin assembly, DNA damage response, and maintenance of genome stability with implications in tumorigenesis. The possibility of RNase P as a therapeutic target in cancer is also discussed.</p>\",\"PeriodicalId\":94020,\"journal\":{\"name\":\"Genomics, proteomics & bioinformatics\",\"volume\":\"22 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-05-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Genomics, proteomics & bioinformatics\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1093/gpbjnl/qzae016\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Genomics, proteomics & bioinformatics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1093/gpbjnl/qzae016","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
核糖核酸酶 P（RNase P）最早于 20 世纪 70 年代被描述为一种内切核糖核酸酶，在前体转运核糖核酸（tRNA）的成熟过程中发挥作用。然而，最近的研究发现了 RNase P 及其成分的非典型作用。在此，我们回顾了 RNase P 参与染色质组装、DNA 损伤反应和维持基因组稳定性的最新进展，以及对肿瘤发生的影响。我们还讨论了将 RNase P 作为癌症治疗靶点的可能性。
Ribonuclease P (RNase P) was first described in the 1970's as an endoribonuclease acting in the maturation of precursor transfer RNAs (tRNAs). More recent studies, however, have uncovered non-canonical roles for RNase P and its components. Here, we review the recent progress of its involvement in chromatin assembly, DNA damage response, and maintenance of genome stability with implications in tumorigenesis. The possibility of RNase P as a therapeutic target in cancer is also discussed.
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