进餐时间对拉丁裔肥胖青少年血糖状况的影响。

IF 2.6 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM
Alaina P Vidmar, Choo Phei Wee, Sarah-Jeanne Salvy, Jomanah Abduljalil Bakhsh, Michael I Goran
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引用次数: 0

摘要

简介迄今为止,还没有一项研究调查了进餐时间如何影响 2 型糖尿病高风险拉丁裔青少年的血糖和胰岛素抵抗。我们进行了一项概念验证研究,采用参与者内部设计,评估 15 名患有肥胖症的拉丁裔青少年在上午、下午和晚上进食测试餐后的代谢反应:方法:13 至 19 岁的肥胖青少年在禁食 16 小时后,分别于不同的日子在三个不同的时间食用相同的测试餐。进食测试餐后,立即进行混合餐耐受性测试(MMTT)。共同主要结果是葡萄糖、胰岛素和 c 肽的曲线下面积(AUC)以及胰岛素生成指数(IGI):22名青少年同意参加,招募率为24%(78%为女性,100%为拉丁裔,平均年龄(16.5±1.3)岁,70%为公费参保)。与上午 8 点相比,下午 4 点后血糖和 c 肽水平的升高幅度明显更大(血糖:p = 0.006;c 肽:p < 0.0001),胰岛素水平与进餐时间之间没有发现明显的关联。配对比较显示,与上午 8 点相比,下午 4 点的 AUC 葡萄糖和 c 肽水平上升幅度更大(葡萄糖 p = 0.003;c 肽 p < 0.001),而胰岛素 AUC 与进餐时间之间没有发现明显的关联(p = 0.09)。与上午 8 点相比,下午 4 点的 IGI 降低幅度更大(p = 0.027):结论:与成人糖尿病高危人群的研究结果类似,拉丁裔肥胖青年在下午和晚上进餐时的胰岛素抵抗比清晨进餐时更严重。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Timing of meal consumption on glucose profiles in Latino adolescents with obesity.

Introduction: To date, there has been no study investigating how meal-timing impacts glucose and insulin resistance among Latino youth at high risk of type 2 diabetes. A proof-of-concept study was conducted to assess metabolic response to a test-meal consumed in the morning, afternoon, and evening among 15 Latino adolescents with obesity using a within-participant design.

Methods: Youth, 13 to 19 years of age, with obesity, consumed the same test-meal after a 16 hour fast at three different times on separate days. Immediately after consumption of the test meal, a mixed meal tolerance test (MMTT) was performed. The co-primary outcomes were the area under the curve (AUC) for glucose, insulin, and c-peptide, and insulinogenic index (IGI).

Results: Twenty-two youth consented to participate for a 24% recruitment rate (78% female, 100% Latino, mean age 16.5±1.3 years, 70% publicly insured). There was a significantly greater rise in glucose and c-peptide levels following at 4 PM compared to 8 AM (glucose: p = 0.006; c-peptide: p < 0.0001) with no significant association found between insulin levels and timing of meal consumption. Pairwise comparisons showed a greater rise in AUC glucose and c-peptide levels at 4 PM compared to 8 AM (glucose p = 0.003; c-peptide p < 0.001) with no significant association found between insulin AUC and timing of meal consumption (p = 0.09). There was a greater reduction in IGI at 4 PM compared to 8 AM (p = 0.027).

Conclusion: Similar to findings in adults at risk for diabetes, Latino youth with obesity show greater insulin resistance in response to a meal consumed in the afternoon and evening compared to early morning food consumption.

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来源期刊
Hormone Research in Paediatrics
Hormone Research in Paediatrics ENDOCRINOLOGY & METABOLISM-PEDIATRICS
CiteScore
4.90
自引率
6.20%
发文量
88
审稿时长
4-8 weeks
期刊介绍: The mission of ''Hormone Research in Paediatrics'' is to improve the care of children with endocrine disorders by promoting basic and clinical knowledge. The journal facilitates the dissemination of information through original papers, mini reviews, clinical guidelines and papers on novel insights from clinical practice. Periodic editorials from outstanding paediatric endocrinologists address the main published novelties by critically reviewing the major strengths and weaknesses of the studies.
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