Amaia Urrizola, Olav Dajani, Nina Aass, Ellen Bjerkeset, Marianne Jensen Hjermstad, Stein Kaasa, Pål Klepstad, Aleksandra Pirnat, Ida Raaness, Hanne Steinsheim, Asta Bye
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引用次数: 0
摘要
目的：在横断面研究中，营养影响症状（NIS）与体重下降（WL）和能量摄入减少有关。我们的目的是确定晚期癌症患者的营养影响症状负担、能量摄入和体重减轻随时间推移的变化之间的关系：一项针对疼痛性骨转移的放疗观察性研究中的成年患者在基线和第八周（W8）使用患者自制主观全面评估工具（PG-SGA）对NIS和WL进行了自我报告。NIS负担是指每位患者的NIS总和，分为0、1-2和≥3，从基线到第8周的变化定义为2点差异。能量摄入量通过 24 小时回忆访谈进行评估：对 111 名患者（72.1%）进行了分析，并按 NIS 负担分组：0 NIS（44.1%）、1-2 NIS（30.6%）和≥3 NIS（25.2%）。与 NIS 负担为 1-2 或 0 的患者相比，NIS 负担≥3 的患者报告的基线 WL 更高（分别为 46.4% vs 18.2% vs 10.2%，P=0.002）。在 W8 期，21 名患者（19%）报告 NIS 负担有所改善，与 NIS 负担加重的患者（17.1%）相比，严重（≥5%）新发 WL 的比例较低（19% vs 42.1%），能量摄入量较高（中位数为 29.6 vs 21.2 千卡/千克）：NIS管理可改善能量摄入并预防WL，强调了系统随访和干预的重要性：NCT02107664。
Nutrition impact symptom monitoring and weight loss outcomes: a longitudinal radiotherapy study.
Objectives: Nutrition impact symptoms (NIS) are associated with weight loss (WL), and decreased energy intake in cross-sectional studies. We aimed to ascertain associations between changes in NIS burden, energy intake and WL over time in patients with advanced cancer.
Methods: Adult patients from an observational radiotherapy study for painful bone metastases self-reported NIS and WL using the Patient-Generated Subjective Global Assessment tool (PG-SGA) at baseline and week eight (W8). NIS burden, the sum of NIS per patient, categorised as 0, 1-2 and ≥3 with changes defined as 2-point differences from baseline to W8 were used. Energy intake was assessed by 24-hour recall interviews.
Results: 111 patients (72.1%) were analysed and grouped by NIS burden; 0 NIS (44.1%), 1-2 NIS (30.6%) and ≥3 NIS (25.2%). Patients with NIS burden of ≥3 reported higher baseline WL compared with those with 1-2 or 0 NIS (46.4% vs 18.2% vs 10.2%, respectively, p=0.002). At W8, 21 patients (19%) reported improved NIS burden, accompanied by a lower proportion of severe (≥5%) new-onset WL (19% vs 42.1%) and higher energy intake (median 29.6 vs 21.2 kcal/kg) than those with worsened NIS burden (17.1%).
Conclusions: NIS management may improve energy intake and prevent WL, emphasising the importance of systematic follow-up and interventions.
期刊介绍：
Published quarterly in print and continuously online, BMJ Supportive & Palliative Care aims to connect many disciplines and specialties throughout the world by providing high quality, clinically relevant research, reviews, comment, information and news of international importance.
We hold an inclusive view of supportive and palliative care research and we are able to call on expertise to critique the whole range of methodologies within the subject, including those working in transitional research, clinical trials, epidemiology, behavioural sciences, ethics and health service research. Articles with relevance to clinical practice and clinical service development will be considered for publication.
In an international context, many different categories of clinician and healthcare workers do clinical work associated with palliative medicine, specialist or generalist palliative care, supportive care, psychosocial-oncology and end of life care. We wish to engage many specialties, not only those traditionally associated with supportive and palliative care. We hope to extend the readership to doctors, nurses, other healthcare workers and researchers in medical and surgical specialties, including but not limited to cardiology, gastroenterology, geriatrics, neurology, oncology, paediatrics, primary care, psychiatry, psychology, renal medicine, respiratory medicine.
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