统计人员与机构动物护理和使用委员会(IACUC)之间的合作。

IF 1.3 4区 医学 Q4 PHARMACOLOGY & PHARMACY
David Potter, Thomas Bradstreet, Davit Sargsyan, Xiao Tan, Vinicius Bonato, Dingzhou Li, John Liang, Ondrej Libiger, Jocelyn Sendecki, John Stansfield, Kanaka Tatikola, Jialin Xu, Brandy Campbell
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引用次数: 0

摘要

在本教程中,我们将探讨统计学家与动物研究机构动物护理和使用委员会 (IACUC) 在动物研究方面的宝贵合作关系,阐明统计学家在确保研究中合乎伦理和科学严谨地使用动物方面发挥的关键作用。医药统计学家日益成为这些委员会的重要成员,在研究设计、数据分析和解释方面贡献专业知识,并在更大范围内促进将良好的统计实践融入实验程序。我们回顾了 "3R "原则(Replacement、Reduction、Refinement),这是在科学研究中人道使用动物的基础,以及统计人员如何与 IACUC 合作,在遵守 3R 原则的同时帮助确保研究的稳健性和可重复性。我们还强调了新出现的关注领域,例如虚拟对照组的使用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The partnership between statisticians and the Institutional Animal Care and Use Committee (IACUC).

In this tutorial we explore the valuable partnership between statisticians and Institutional Animal Care and Use Committees (IACUCs) in the context of animal research, shedding light on the critical role statisticians play in ensuring the ethical and scientifically rigorous use of animals in research. Pharmaceutical statisticians have increasingly become vital members of these committees, contributing expertise in study design, data analysis, and interpretation, and working more generally to facilitate the integration of good statistical practices into experimental procedures. We review the "3Rs" principles (Replacement, Reduction, and Refinement) which are the foundation for the humane use of animals in scientific research, and how statisticians can partner with IACUC to help ensure robust and reproducible research while adhering to the 3Rs principles. We also highlight emerging areas of interest, such as the use of virtual control groups.

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来源期刊
Pharmaceutical Statistics
Pharmaceutical Statistics 医学-统计学与概率论
CiteScore
2.70
自引率
6.70%
发文量
90
审稿时长
6-12 weeks
期刊介绍: Pharmaceutical Statistics is an industry-led initiative, tackling real problems in statistical applications. The Journal publishes papers that share experiences in the practical application of statistics within the pharmaceutical industry. It covers all aspects of pharmaceutical statistical applications from discovery, through pre-clinical development, clinical development, post-marketing surveillance, consumer health, production, epidemiology, and health economics. The Journal is both international and multidisciplinary. It includes high quality practical papers, case studies and review papers.
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