利用小干扰 RNA 靶向树突状细胞进行免疫调节的最新进展。

IF 2.2 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Current molecular medicine Pub Date : 2024-06-07 DOI:10.2174/0115665240303370240530120450

Mahshid Shahverdi, Vahab Alamdari-Palangi, Shiva Alipour, Amir Ghaffari Jolfayi, Javad Masoumi, Leili Aghebati-Maleki, Arman Rostamlou, Behzad Baradaran

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引用次数: 0

摘要

通过 RNA 干扰（RNAi）技术进行基因沉默为特异性敲除与疾病相关的基因表达提供了有力的治疗方法。小干扰 RNA（siRNA）可以启动一个特异性降解和沉默同源 mRNA 表达的过程。这些 RNA 干扰过程可以有效调整许多生物过程，包括免疫反应。树突状细胞（DC）是专门的抗原递呈细胞，在调节先天性免疫和适应性免疫方面具有强大的功能。SiRNA 在协调由 DCs 介导的免疫过程中发挥着重要作用。本综述介绍了 siRNAs 在 DC 免疫调节中的重要作用，并强调了其在改善基于 DC 的免疫疗法中的潜在应用。

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Recent Advances in Immune Regulation by Targeting Dendritic Cells using Small Interfering RNAs.

Gene silencing through RNA interference (RNAi) technology has provided forceful therapeutic modalities to specific knockdown of the genes' expression related to diseases. Small interfering RNAs (siRNAs) can start a process that specifically degrades and silences the expression of cognate mRNAs. These RNA interference processes could effectively adjust many biological processes, including immune responses. Dendritic cells (DCs) are specialist antigen-presenting cells with potent functions in regulating innate and adaptive immunity. SiRNAs performed vital roles in coordinating immune processes mediated by DCs. This review describes the findings that shed light on the significance of siRNAs in DC immune regulation and highlight their potential applications for improving DC-based immunotherapies.

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来源期刊

Current molecular medicine 医学-医学：研究与实验

CiteScore

5.00

自引率

4.00%

发文量

141

审稿时长

4-8 weeks

期刊介绍： Current Molecular Medicine is an interdisciplinary journal focused on providing the readership with current and comprehensive reviews/ mini-reviews, original research articles, short communications/letters and drug clinical trial studies on fundamental molecular mechanisms of disease pathogenesis, the development of molecular-diagnosis and/or novel approaches to rational treatment. The reviews should be of significant interest to basic researchers and clinical investigators in molecular medicine. Periodically the journal invites guest editors to devote an issue on a basic research area that shows promise to advance our understanding of the molecular mechanism(s) of a disease or has potential for clinical applications.