牵手成功的免疫疗法：CD8+ T 细胞和 M1 样巨噬细胞互换指挥棒

IF 48.8 1区医学 Q1 CELL BIOLOGY

Cancer Cell Pub Date : 2024-06-10 DOI:10.1016/j.ccell.2024.05.012

Abir Hussein, Slava Stamova, Maria Xydia, Philipp Beckhove

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引用次数: 0

摘要

癌症免疫疗法是临床肿瘤学的支柱，但只有少数病例能实现长期缓解。在本期杂志中，van Elsas 等人的研究表明，有效的免疫疗法需要一系列由 CD8+ T 细胞协调的过程，这些过程会导致 M1 样巨噬细胞的招募和局部激活。

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Hand in hand to successful immunotherapy: CD8+ T cells and M1-like macrophages swap the baton

Cancer immunotherapy is a pillar of clinical oncology but only achieves long-term remissions in a minority of cases. In this issue, van Elsas et al. show that effective immunotherapy requires a series of processes orchestrated by CD8⁺ T cells that result in the recruitment and local activation of M1-like macrophages.

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来源期刊

Cancer Cell 医学-肿瘤学

CiteScore

55.20

自引率

1.20%

发文量

179

审稿时长

4-8 weeks

期刊介绍： Cancer Cell is a journal that focuses on promoting major advances in cancer research and oncology. The primary criteria for considering manuscripts are as follows: Major advances: Manuscripts should provide significant advancements in answering important questions related to naturally occurring cancers. Translational research: The journal welcomes translational research, which involves the application of basic scientific findings to human health and clinical practice. Clinical investigations: Cancer Cell is interested in publishing clinical investigations that contribute to establishing new paradigms in the treatment, diagnosis, or prevention of cancers. Insights into cancer biology: The journal values clinical investigations that provide important insights into cancer biology beyond what has been revealed by preclinical studies. Mechanism-based proof-of-principle studies: Cancer Cell encourages the publication of mechanism-based proof-of-principle clinical studies, which demonstrate the feasibility of a specific therapeutic approach or diagnostic test.