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M2毒蕈碱受体的新功能

IF 13.9 1区 医学 Q1 PHARMACOLOGY & PHARMACY
Trends in pharmacological sciences Pub Date : 2024-08-01 Epub Date: 2024-06-08 DOI:10.1016/j.tips.2024.05.010
Jürgen Wess, Liu Liu
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引用次数: 0

摘要

M2 muscarinic 受体（M2R）是 A 类 G 蛋白偶联受体（GPCR）的原型。有趣的是，Fasciani 等人最近在 M2 受体 mRNA 中发现了一个内部翻译起始位点，可引导 C 端受体片段的表达。这种多肽在细胞受压时会升高，并定位到线粒体，抑制线粒体的氧化磷酸化。
本文章由计算机程序翻译，如有差异，请以英文原文为准。
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A novel function of the M2 muscarinic receptor.

The M2 muscarinic receptor (M2R) is a prototypic class A G protein-coupled receptor (GPCR). Interestingly, Fasciani et al. recently identified an internal translation start site within the M2 receptor mRNA, directing the expression of a C-terminal receptor fragment. Elevated during cellular stress, this polypeptide localizes to mitochondria where it inhibits oxidative phosphorylation.

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来源期刊
Trends in pharmacological sciences
Trends in pharmacological sciences 医学-药学
CiteScore
23.90
自引率
0.70%
发文量
132
审稿时长
6-12 weeks
期刊介绍： Trends in Pharmacological Sciences (TIPS) is a monthly peer-reviewed reviews journal that focuses on a wide range of topics in pharmacology, pharmacy, pharmaceutics, and toxicology. Launched in 1979, TIPS publishes concise articles discussing the latest advancements in pharmacology and therapeutics research. The journal encourages submissions that align with its core themes while also being open to articles on the biopharma regulatory landscape, science policy and regulation, and bioethics. Each issue of TIPS provides a platform for experts to share their insights and perspectives on the most exciting developments in the field. Through rigorous peer review, the journal ensures the quality and reliability of published articles. Authors are invited to contribute articles that contribute to the understanding of pharmacology and its applications in various domains. Whether it's exploring innovative drug therapies or discussing the ethical considerations of pharmaceutical research, TIPS provides a valuable resource for researchers, practitioners, and policymakers in the pharmacological sciences.
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