预测结直肠癌中绒毛蛋白的表达和肿瘤行为

Q3 Medicine
Seyed Amir Miratashi Yazdi , Elahe Farmani , Sara Shahvaisi , Arezoo Eftekhar Javadi , Elham Nazar
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引用次数: 0

摘要

背景大肠癌是最常见的癌症之一,也是全球癌症相关死亡的主要原因。本研究是一项横断面研究,使用的是 2021 年至 2022 年期间在新浪医院接受手术的 106 例患者的组织样本。结果在这项研究中,我们观察到绒毛蛋白表达与肿瘤深度之间存在显著关联,绒毛蛋白表达与肿瘤位置(结肠或直肠)之间也存在相关性。然而,绒毛蛋白表达与受累淋巴结数量、年龄、性别、肿瘤分级和大小之间没有关联。此外,绒毛蛋白的表达与肿瘤血管或神经侵犯之间也没有明显的关联。因此,需要新的生物标志物来识别有局部和远处转移风险的患者,并对患者进行适当的治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Prediction of villin expression and tumor behavior in colorectal cancer

Background

Colorectal cancer is one of the most common cancers and the leading cause of cancer-related deaths worldwide. The incidence is gradually increasing, and the mortality and recurrence rates of the disease remain high.

Methods

This study was conducted as a cross-sectional study using tissue samples of 106 patients who underwent surgery at Sina Hospital from 2021 to 2022. After histopathological examination and identification of the pathological features of the tumor, the samples were subjected to immunohistochemical staining using a monoclonal antibody against villin.

Results

In this study, we observed a significant association between villin expression and tumor depth, as well as a correlation between villin expression and tumor location (colon or rectum). However, no association was found between villin expression and the number of affected lymph nodes and age, sex, tumor grade, and size. Furthermore, there was no significant association between villin expression and tumor vascular or neural invasion.

Conclusion

The extent of local invasion and metastasis are important factors in disease progression and can lead to treatment failure. Therefore, new biomarkers are needed to identify patients at risk of local and distant metastases and to enable appropriate treatment of patients.

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来源期刊
CiteScore
4.30
自引率
0.00%
发文量
148
审稿时长
56 days
期刊介绍: Cancer Treatment and Research Communications is an international peer-reviewed publication dedicated to providing comprehensive basic, translational, and clinical oncology research. The journal is devoted to articles on detection, diagnosis, prevention, policy, and treatment of cancer and provides a global forum for the nurturing and development of future generations of oncology scientists. Cancer Treatment and Research Communications publishes comprehensive reviews and original studies describing various aspects of basic through clinical research of all tumor types. The journal also accepts clinical studies in oncology, with an emphasis on prospective early phase clinical trials. Specific areas of interest include basic, translational, and clinical research and mechanistic approaches; cancer biology; molecular carcinogenesis; genetics and genomics; stem cell and developmental biology; immunology; molecular and cellular oncology; systems biology; drug sensitivity and resistance; gene and antisense therapy; pathology, markers, and prognostic indicators; chemoprevention strategies; multimodality therapy; cancer policy; and integration of various approaches. Our mission is to be the premier source of relevant information through promoting excellence in research and facilitating the timely translation of that science to health care and clinical practice.
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