低镁血症可能与老年人的虚弱、步态和平衡问题以及基本的日常生活活动有关。

IF 1.1 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL
Acta Clinica Belgica Pub Date : 2024-06-01 Epub Date: 2024-06-07 DOI:10.1080/17843286.2024.2364143
Suleyman Emre Kocyigit, Bilal Katipoglu
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引用次数: 0

摘要

研究目的该研究旨在探讨低镁血症、临床前低镁血症和正常镁血症与老年综合征和老年综合指标(CGA)之间的关系。所有患者均接受了 CGA 检查。患者被分为三组:镁(Mg)水平≤1.5 mg/dL、Mg水平1.5-1.8 mg/dL、Mg水平>1.8 mg/dL。这三个组别在人口统计学特征、合并症、CGA参数和老年综合征方面进行了比较。在对混杂因素进行调整后,对重要参数进行了回归分析:74.9%的参与者为女性,平均年龄为(76.5 ± 6.6)岁。低镁血症发生率为 14.2%。三组患者的人口统计学特征和用药情况(包括质子泵抑制剂和利尿剂)相似。低镁血症组的 FRIED 虚弱量表和定时起立行走测试持续时间较长,而低镁血症组的基本日常活动量(ADLs)和 Tinetti-POMA(以表现为导向的行动能力评估)评分较低。以正常镁血症为参照组时,FRIED虚弱量表、基本日常生活能力和POMA评分在低镁血症组更显著(分别为p = 0.025、p = 0.013和p = 0.011),但在临床前低镁血症组,无论协变量如何,均无显著性差异:结论:低镁血症,尤其是血清镁水平低于 1.5 毫克/分升,可能与体弱、基本日常活动能力、步态和平衡测试有关。在老年医学实践中,应从上述疾病风险的角度对低镁血症患者进行评估。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Hypomagnesemia may be related to frailty, gait and balance problems, and basic activities of daily living in older adults.

Objectives: The study aims to investigate the relationship between hypomagnesemia, preclinical hypomagnesemia, and normomagnesemia as along with geriatric syndrome and comprehensive geriatric parameters(CGA).

Methods: 217 patients who applied to the geriatric clinic between November 2022 and December 2023 were included in the study. All patients underwent CGA. Patients were categorized into three groups: Magnesium (Mg) level ≤ 1.5 mg/dL, Mg level 1.5-1.8 mg/dL, and Mg level > 1.8 mg/dL. These three groups were compared in terms of demographic characteristics, comorbidities, CGA parameters, and geriatric syndromes. Regression analyses was conducted for significant parameters, adjusting for confounders.

Results: 74.9% of all participants were female, with an average age of 76.5 ± 6.6 years. The frequency of hypomagnesemia was 14.2%. Demographic characteristics and medication use, including proton pump inhibitors and diuretics, were similar in these three groups. While the FRIED frailty scale and the duration of the timed-up-and-go test were higher in the hypomagnesemia group, the Basic Activities Daily of Living (ADLs) and the Tinetti-POMA(performance-oriented mobility assessment) scores were lower in the hypomagnesemia group. When normomagnesemia was accepted as the reference category, FRIED frailty scale, Basic ADLs, and POMA score were more significant in the hypomagnesemia group (p = 0.025, p = 0.013 and p = 0.011,respectively), but there was no significance in the preclinical hypomagnesemia group regardless of the covariates.

Conclusion: Hypomagnesemia, particularly serum Mg levels below 1.5 mg/dL, may be associated with frailty, basic ADLs, gait, and balance tests. In geriatric practice, patients with hypomagnesemia should be evaluated in terms of the risk of the mentioned disorders.

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来源期刊
Acta Clinica Belgica
Acta Clinica Belgica MEDICINE, GENERAL & INTERNAL-
CiteScore
3.50
自引率
0.00%
发文量
44
期刊介绍: Acta Clinica Belgica: International Journal of Clinical and Laboratory Medicine primarily publishes papers on clinical medicine, clinical chemistry, pathology and molecular biology, provided they describe results which contribute to our understanding of clinical problems or describe new methods applicable to clinical investigation. Readership includes physicians, pathologists, pharmacists and physicians working in non-academic and academic hospitals, practicing internal medicine and its subspecialties.
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