{"title":"吡啶-3-基)咪唑并[2,1-b][1,3,4]噻二唑与 1,3,4-恶二唑连接的酰胺衍生物的合理设计、合成和抗癌评估","authors":"Khasim Saheb Shaik , Saritha N , Nagendra Reddy G","doi":"10.1016/j.cdc.2024.101147","DOIUrl":null,"url":null,"abstract":"<div><p>A new series of amides of pyridin-3-yl)imidazo[2,1-b][1,3,4]thiadiazoles (<strong>13a-j</strong>) have been developed and confirmed by <sup>1</sup>HNMR, <sup>13</sup>CNMR and mass spectral data. Further, in the vitro anticancer activity of newly prepared compounds <strong>13a-j</strong> was examined against four human cancer cell lines including MCF-7 & MDA MB-231 (human breast cancer), A549 (human lung cancer) and DU-145 (human prostate cancer) by employing the MTT assay, and using etoposide as a standard reference. These results indicated that the most of the derivatives displayed excellent to moderate anticancer activity. Among the five compounds <strong>13a, 13b, 13c, 13d</strong> and <strong>13e</strong> demonstrated remarkable activity as standard. One of the compounds <strong>13a</strong> displayed excellent activity.</p></div>","PeriodicalId":269,"journal":{"name":"Chemical Data Collections","volume":"52 ","pages":"Article 101147"},"PeriodicalIF":2.2180,"publicationDate":"2024-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Rational design, synthesis, and anticancer evaluation of amide derivatives of Pyridin3-yl)imidazo[2,1-b][1,3,4]thiadiazole linked 1,3,4-oxadiazoles\",\"authors\":\"Khasim Saheb Shaik , Saritha N , Nagendra Reddy G\",\"doi\":\"10.1016/j.cdc.2024.101147\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>A new series of amides of pyridin-3-yl)imidazo[2,1-b][1,3,4]thiadiazoles (<strong>13a-j</strong>) have been developed and confirmed by <sup>1</sup>HNMR, <sup>13</sup>CNMR and mass spectral data. Further, in the vitro anticancer activity of newly prepared compounds <strong>13a-j</strong> was examined against four human cancer cell lines including MCF-7 & MDA MB-231 (human breast cancer), A549 (human lung cancer) and DU-145 (human prostate cancer) by employing the MTT assay, and using etoposide as a standard reference. These results indicated that the most of the derivatives displayed excellent to moderate anticancer activity. Among the five compounds <strong>13a, 13b, 13c, 13d</strong> and <strong>13e</strong> demonstrated remarkable activity as standard. One of the compounds <strong>13a</strong> displayed excellent activity.</p></div>\",\"PeriodicalId\":269,\"journal\":{\"name\":\"Chemical Data Collections\",\"volume\":\"52 \",\"pages\":\"Article 101147\"},\"PeriodicalIF\":2.2180,\"publicationDate\":\"2024-06-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Chemical Data Collections\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2405830024000351\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"Chemistry\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemical Data Collections","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2405830024000351","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Chemistry","Score":null,"Total":0}
Rational design, synthesis, and anticancer evaluation of amide derivatives of Pyridin3-yl)imidazo[2,1-b][1,3,4]thiadiazole linked 1,3,4-oxadiazoles
A new series of amides of pyridin-3-yl)imidazo[2,1-b][1,3,4]thiadiazoles (13a-j) have been developed and confirmed by 1HNMR, 13CNMR and mass spectral data. Further, in the vitro anticancer activity of newly prepared compounds 13a-j was examined against four human cancer cell lines including MCF-7 & MDA MB-231 (human breast cancer), A549 (human lung cancer) and DU-145 (human prostate cancer) by employing the MTT assay, and using etoposide as a standard reference. These results indicated that the most of the derivatives displayed excellent to moderate anticancer activity. Among the five compounds 13a, 13b, 13c, 13d and 13e demonstrated remarkable activity as standard. One of the compounds 13a displayed excellent activity.
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Chemical Data Collections (CDC) provides a publication outlet for the increasing need to make research material and data easy to share and re-use. Publication of research data with CDC will allow scientists to: -Make their data easy to find and access -Benefit from the fast publication process -Contribute to proper data citation and attribution -Publish their intermediate and null/negative results -Receive recognition for the work that does not fit traditional article format. The research data will be published as ''data articles'' that support fast and easy submission and quick peer-review processes. Data articles introduced by CDC are short self-contained publications about research materials and data. They must provide the scientific context of the described work and contain the following elements: a title, list of authors (plus affiliations), abstract, keywords, graphical abstract, metadata table, main text and at least three references. The journal welcomes submissions focusing on (but not limited to) the following categories of research output: spectral data, syntheses, crystallographic data, computational simulations, molecular dynamics and models, physicochemical data, etc.
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