热捧semaglutide

Ruby Dhar, Arun Kumar, Subhradip Karmakar
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摘要

塞马鲁肽(Ozempic acid)属于胰高血糖素样肽-1(GLP-1)受体激动剂类药物。这类药物可以模拟一种叫做 GLP-1 的激素的作用,这种激素有助于调节血糖和促进减肥。GLP-1 的作用之一是促使人体产生更多的胰岛素,从而降低血糖(葡萄糖)。正因为如此,医生们使用塞马鲁肽治疗 2 型糖尿病已有 15 年之久。然而,较高剂量的 GLP-1 也会通过与负责抑制食欲的脑区相互作用而导致缺氧。如果与饮食和运动相结合,它可以帮助肥胖或超重的人减轻大量体重,降低患糖尿病、心脏病和癌症的风险。塞马鲁肽的这一功效使其成为减肥的合适候选药物。目前,塞马鲁肽仅以 Wegovy 的品牌名称获准用于减肥。公众对减肥的需求和狂热促使了塞马鲁肽的使用和滥用。随着人们对减肥计划的兴趣和痴迷程度不断增加,医疗保健专业人员不得不改进策略以满足需求。满足需求的方法之一是开具其他品牌的塞马鲁肽处方,如 Ozempic 和 Rybelsus(因不同原因使用食品药品管理局(FDA)批准的药物)。如果您符合以下条件之一,美国食品及药物管理局(FDA)建议您使用韦格威(Wegovy)进行减肥:FDA规定,只有当体重指数(BMI)大于或等于27 kg/m2,同时患有高血压、2型糖尿病或高胆固醇等其他合并症,或者体重指数大于或等于30 kg/m2时,才可使用塞马鲁肽。这种情况已经变得非常普遍,以至于需要使用semaglutide来控制血糖的真正用户发现货架上不见了semaglutide。过度使用或使用不当往往会带来不良后果,如低血糖、精神错乱、头晕、癫痫发作、头痛,甚至失去知觉。对塞马鲁肽的热捧需要在服用前谨慎权衡。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The craze with semaglutide
Semaglutide (Ozempic acid) belongs to a class of drugs called glucagon-like peptide-1 (GLP-1) receptor agonists. These medications mimic the action of a hormone called GLP-1, which helps regulate blood glucose and promotes weight loss. One role of GLP-1 is to prompt the body to produce more insulin, which reduces blood sugar (glucose). Because of this, doctors have been treating type 2 diabetes with semaglutide for more than 15 years. Higher doses of GLP-1, however, also cause anoxia by interacting with the brain regions responsible for appetite suppression. When combined with diet and exercise, it can help people who are obese or overweight lose a significant amount of weight and lower their risk of developing diabetes, heart disease, and cancer. This effect of Semaglutide made it an appropriate candidate for weight loss. At present, semaglutide is only approved for weight loss under the brand name Wegovy. Public demand and craze for weight loss have prompted the usage and misusage of semaglutide. As interest and obsession with weight loss programs continue to grow, health-care professionals are forced to improvise their strategy to manage the demand. One way to meet needs is to prescribe other brands of semaglutide, such as Ozempic and Rybelsus (using a Food and Drug Administration [FDA]-approved drug for a different reason). The FDA recommends Wegovy for weight loss if you meet one of the following criteria: The FDA guidelines for semaglutide usage only if body mass index (BMI) is 27 kg/m2 or greater along with other co-morbidities such as high blood pressure, type 2 diabetes, or high cholesterol or a BMI >30 kg/m2. This has become so rampant that genuine users of semaglutide who need it for managing their blood sugar are finding it missing from the shelf. Overuse or improper use often comes with adverse consequences, such as hypoglycemia, confusion, dizziness, seizures, headache, and even loss of consciousness. The craze for semaglutide needs to be cautiously weighed before consumption.
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