富法尔(阿瑞卡坚果)的药理评价和质量控制参数开发

Usha Devi, S. A. Ansari, Asma Sattar Khan, Anees Ahmad, Mohammed Wasim Ahmed, Rampratap Meena
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引用次数: 0

摘要

Areca catechu 的种子通常被称为 "Areca nut "或 "Betel nut",属于 Arecaceae 科。它原产于马来西亚,在中国南方和印度的亚热带地区种植,是具有重要经济价值的种子作物。槟榔呈红褐色至浅黄褐色,质地坚硬,卵圆形、椭圆形或球形,内部有反刍的褐色胚乳组织与白色组织交替分布。在印度传统医学体系中,阿瑞卡坚果被认为是重要的单一药物之一,在阿育吠陀、悉达和尤那尼制剂的许多配方中都有治疗作用。药用植物中具有生物活性的植物化学物质是其各种药理特性的主要原因。人们普遍认为,药用植物可以安全有效地治疗各种疾病。药用植物具有抗霉菌、抗真菌、抗病毒、抗菌、抗炎、免疫调节、降血糖和抗氧化等多种药理作用。在乌纳尼医学体系的经典文献中,阿瑞卡坚果通常被称为 "Fufal",被认为具有收敛、利尿、通便和滋补神经的作用。局部用药对急性炎症、沙眼、脓疱疮、牙龈炎很有用,还能补益心脏。在当前形势下,由于对草药的需求不断增长,草药材料的快速标准化已成为一项重大挑战。虽然草药普遍有效,但掺假和缺乏标准化可能会影响其有效性。本研究的重点是通过制定不同的药学标准,如宏观镜检、显微镜检、理化分析和 HPTLC 指纹图谱,对阿雷卡果进行鉴定。市场上的大多数样品要么受到致癌真菌的污染,要么掺杂了有害化学物质、杀虫剂和重金属,这些物质已知会对人类造成多种健康问题。因此,我们还对药物的几个质量参数进行了评估,如重金属、微生物含量、黄曲霉毒素和杀虫剂。目前的研究数据可作为验证阿雷卡坚果纯度、安全性和有效性的参考标准。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Pharmacognostic evaluation and development of quality control parameters for Fufal (Areca nut)
Seed of Areca catechu commonly known as ‘Areca nut’ or ‘Betel nut’ belongs to Arecaceae family. It is native to Malaysia and cultivated in subtropical region of South China and India for their economically important seed crop. Areca nut is reddish to light yellowish brown, hard, ovoid, ellipsoidal or globose, internally are mottled with ruminated brownish endosperm tissue alternating with white tissue. In the Indian traditional medicine system Areca nut has been considered one of the important single drug which is therapeutically useful in a number of formulations of Ayurveda, Siddha and Unani preparation. The presence of bioactive phytochemicals in medicinal plants is mainly responsible for various pharmacological properties. It has been widely accepted that medicinal plants are safe and effective treatments for various diseases and ailments. Several pharmacological activities such as antimycotic, antifungal, antiviral, antibacterial, anti-inflammatory, immunomodulatory, hypoglycemic and antioxidant activities are attributed to it. In classical literature of Unani system of medicine, Areca nut is commonly called ‘Fufal’ and considered astringent, diuretic, emmenogogue, nervine tonic. Local application is useful in acute inflammation, trachoma, sialorrhea, gingivitis and as a tonic for heart. In the current scenario, standardizing herbal materials at a rapid pace has become a major challenge due to the growing demand for herbal medicines. Although herbal drugs are generally effective, and their effectiveness can be impacted by adulteration and lack of standardization. The present study is focused on authentication of the Areca nut by developing different pharmacognostic standards such as macroscopy, microscopy, physicochemical analysis and HPTLC fingerprinting. The majority of the market sample are either contaminated by cancer-causing fungi or adulterated with harmful chemicals, pesticides, and heavy metals that known to cause several health problems on human beings. So, the drug was also evaluated for several quality parameters, like heavy metals, microbial load, aflatoxins, and pesticides. The current study data can serve as reference standards for verifying Areca nut's purity, safety, and effectiveness.
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