可见光催化 N,N-二甲基苯胺和芳基醛合成氨基醇

IF 1.4 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Chemistry Letters Pub Date : 2024-06-03 DOI:10.1093/chemle/upae112

Jia-Hui Jin, Yi-Jian Ma, Yu-Yun Yin, Fu-Gang Zhao, Cheng-Shuo Shen, Cheng-Miao Xu, Yong-Miao Shen

{"title":"可见光催化 N,N-二甲基苯胺和芳基醛合成氨基醇","authors":"Jia-Hui Jin, Yi-Jian Ma, Yu-Yun Yin, Fu-Gang Zhao, Cheng-Shuo Shen, Cheng-Miao Xu, Yong-Miao Shen","doi":"10.1093/chemle/upae112","DOIUrl":null,"url":null,"abstract":"\n Herein, we describe a direct radical addition reaction of aryl aldehyde and N, N-dimethylaniline using iridium complex as photocatalysts to form amino alcohols under mild conditions, which exhibit an excellent convenient and sustainable methodology. The reaction could be easily scale up through continuous flow with high yield. Mechanism studies with the assistance of DFT calculations indicated such a reaction undertaking a radical pathway.","PeriodicalId":9862,"journal":{"name":"Chemistry Letters","volume":null,"pages":null},"PeriodicalIF":1.4000,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Visible-light-catalyzed Synthesis of Amino Alcohols from N,N-dimethylaniline and Aryl Aldehyde\",\"authors\":\"Jia-Hui Jin, Yi-Jian Ma, Yu-Yun Yin, Fu-Gang Zhao, Cheng-Shuo Shen, Cheng-Miao Xu, Yong-Miao Shen\",\"doi\":\"10.1093/chemle/upae112\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"\\n Herein, we describe a direct radical addition reaction of aryl aldehyde and N, N-dimethylaniline using iridium complex as photocatalysts to form amino alcohols under mild conditions, which exhibit an excellent convenient and sustainable methodology. The reaction could be easily scale up through continuous flow with high yield. Mechanism studies with the assistance of DFT calculations indicated such a reaction undertaking a radical pathway.\",\"PeriodicalId\":9862,\"journal\":{\"name\":\"Chemistry Letters\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.4000,\"publicationDate\":\"2024-06-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Chemistry Letters\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1093/chemle/upae112\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemistry Letters","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1093/chemle/upae112","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

摘要

在此，我们以铱络合物为光催化剂，描述了芳基醛与 N，N-二甲基苯胺在温和条件下直接发生自由基加成反应生成氨基醇的过程，展示了一种非常便捷且可持续的方法。该反应很容易通过连续流进行放大，而且产率高。借助 DFT 计算进行的机理研究表明，该反应采用了自由基途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Visible-light-catalyzed Synthesis of Amino Alcohols from N,N-dimethylaniline and Aryl Aldehyde

Herein, we describe a direct radical addition reaction of aryl aldehyde and N, N-dimethylaniline using iridium complex as photocatalysts to form amino alcohols under mild conditions, which exhibit an excellent convenient and sustainable methodology. The reaction could be easily scale up through continuous flow with high yield. Mechanism studies with the assistance of DFT calculations indicated such a reaction undertaking a radical pathway.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Chemistry Letters 化学-化学综合

CiteScore

3.00

自引率

6.20%

发文量

260

审稿时长

1.2 months

期刊介绍： Chemistry Letters covers the following topics: -Organic Chemistry- Physical Chemistry- Inorganic Chemistry- Analytical Chemistry- Materials Chemistry- Polymer Chemistry- Supramolecular Chemistry- Organometallic Chemistry- Coordination Chemistry- Biomolecular Chemistry- Natural Products and Medicinal Chemistry- Electrochemistry