保法止是否弊大于利?评估非那雄胺对男性健康的生殖和非生殖影响

Alexander Sukharev, Tami Alade, Veranca Shah, Sophia Dahmani
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引用次数: 0

摘要

非那雄胺(市场名为 "保法止")是一种强效的 5α 还原酶抑制剂,是治疗男性秃发的一线药物。尽管非那雄胺具有促进毛发生长的功效,但人们担心它对男性生殖系统的影响,因为使用非那雄胺与性欲减退、勃起功能障碍和潜在的生精功能障碍有关。也有记录表明,该药物会诱发抑郁等非生殖不良反应。目前的研究表明,非那雄胺对神经类固醇激素水平的改变可能是导致这些不良反应的原因之一。本文利用循证研究评估了非那雄胺对男性生殖健康的短期和长期影响。总之,文献中似乎存在相互矛盾的证据,既有支持非那雄胺不良影响的数据,也有反对非那雄胺不良影响的数据。不过,在研究和临床环境中,这些病例的发生率相当低,这一点似乎已达成共识。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Does Propecia Cause More Harms than Good: Assessing Reproductive and Non-Reproductive Effects of Finasteride on Male Health
Finasteride (marketed as Propecia) is a potent 5α-reductase inhibitor used as first-line treatment for male pattern baldness. Despite finasteride’s efficacy in promoting hair growth, there is concern about its impact on male reproduction because finasteride use has been linked to reduced libido, erectile dysfunction, and potential spermatogenic failure. The drug has also been documented to induce nonreproductive adverse effects such as depression. Current research suggests that finasteride’s alteration of neurosteroid hormone levels may be contributing to these adverse effects. This article used evidence-based research to evaluate finasteride’s short- and long-term effects on male reproductive health. In summary, there appears to be contradictory evidence within the literature with data both in support and in opposition of finasteride’s adverse effects. There does, however, seem to be consensus on the incidence of these cases being quite low within both research and clinical settings.
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