通过钯催化胺化引入双(5-(三氟甲基)吡啶-2-基)胺螯合单元

Molbank Pub Date : 2024-06-04 DOI:10.3390/m1831

Nikolay A. Korinskiy, A. Abel, Violetta A. Ionova, S. Bezzubov, A. Averin, Irina P. Beletskaya

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引用次数: 0

摘要

我们报告了一步合成三氟甲基取代的二(吡啶-2-基)胺配体的方法。在 Pd(dba)2/BINAP 催化体系存在下，通过钯催化的胺化反应，从 2-溴-5-(三氟甲基)吡啶和相应的芳香胺中获得了 N-（杂）芳基取代的双（5-（三氟甲基）吡啶-2-基）胺。制备出了四种新配体，产率从高到好，并通过核磁共振、红外光谱和质谱进行了表征。其中一种产物的结构还得到了 X 射线分析的支持。

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Introducing Bis(5-(Trifluoromethyl)pyridin-2-yl)amine Chelating Unit via Pd-Catalyzed Amination

We report a one-step synthesis of trifluoromethyl-substituted di(pyridin-2-yl)amine-based ligands. N-(hetero)aryl-substituted bis(5-(trifluoromethyl)pyridin-2-yl)amines were obtained from 2-bromo-5-(trifluoromethyl)pyridine and corresponding aromatic amines via Pd-catalyzed amination reaction in the presence of a Pd(dba)2/BINAP catalytic system. Four new ligands were prepared in good to high yields and characterized by NMR, IR spectroscopies and mass spectrometry. The structure of one of the products was additionally supported by X-ray analysis.

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Molbank

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