Kellyn M Spychala, Ellen W Yeung, Alex P Miller, Wendy S Slutske, Action Consortium, Kirk C Wilhelmsen, Ian R Gizer
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These PRSs were used to predict the phenotype of alcohol-related aggression among drinkers in two independent samples: the University of California at San Francisco (UCSF) Family Alcoholism Study (<i>n</i> = 1,162) and the National Longitudinal Study of Adolescent to Adult Health (Add Health; <i>n</i> = 4,291).</p><p><strong>Results: </strong>There were significant associations between the AUD PRS and lifetime alcohol-related aggression in the UCSF study sample. Additionally, the trait aggression PRS was associated with three or more experiences of hitting anyone else and getting into physical fights while under the influence of alcohol, along with a composite score of three or more experiences of alcohol-related aggression, in the UCSF study sample. No significant associations were observed in the Add Health sample. Limited sex-specific genetic effects were observed.</p><p><strong>Conclusions: </strong>These results provide preliminary evidence that genetic influences underlying alcohol use and aggression are uniquely associated with alcohol-related aggression and suggest that these associations may differ by type and frequency of alcohol-related aggression incidents. (PsycInfo Database Record (c) 2024 APA, all rights reserved).</p>","PeriodicalId":48325,"journal":{"name":"Psychology of Addictive Behaviors","volume":" ","pages":""},"PeriodicalIF":3.2000,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Genetic risk for trait aggression and alcohol use predict unique facets of alcohol-related aggression.\",\"authors\":\"Kellyn M Spychala, Ellen W Yeung, Alex P Miller, Wendy S Slutske, Action Consortium, Kirk C Wilhelmsen, Ian R Gizer\",\"doi\":\"10.1037/adb0001015\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>A propensity for aggression or alcohol use may be associated with alcohol-related aggression. 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Limited sex-specific genetic effects were observed.</p><p><strong>Conclusions: </strong>These results provide preliminary evidence that genetic influences underlying alcohol use and aggression are uniquely associated with alcohol-related aggression and suggest that these associations may differ by type and frequency of alcohol-related aggression incidents. 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引用次数: 0
摘要
目的：攻击倾向或饮酒可能与酒精相关的攻击行为有关。以往的研究表明，酒精使用和攻击行为之间存在遗传重叠，但尚未研究与酒精相关的攻击行为如何受到攻击行为或酒精使用遗传风险的独特影响。本研究采用多基因风险评分（PRS）方法研究了特质攻击性、酒精使用和酒精使用障碍（AUD）的遗传风险与酒精相关攻击性之间的关联：方法：利用全基因组关联研究的汇总统计数据，创建了特质攻击性、酒精消费和酒精使用障碍的 PRSs。这些PRS用于预测两个独立样本中饮酒者与酒精相关的攻击行为的表型：加州大学旧金山分校（UCSF）家庭酗酒研究（n = 1,162）和全国青少年到成人健康纵向研究（Add Health; n = 4,291）：结果：在加州大学旧金山分校的研究样本中，AUD PRS与终生与酒精相关的攻击行为之间存在明显关联。此外，在加州大学旧金山分校的研究样本中，特质侵犯 PRS 与三次或三次以上在酒精影响下殴打他人和发生肢体冲突的经历有关，同时还与三次或三次以上与酒精有关的侵犯经历的综合得分有关。在 Add Health 样本中没有观察到明显的关联。研究还观察到了有限的性别特异性遗传效应：这些结果提供了初步证据，证明酒精使用和攻击行为的遗传影响与酒精相关攻击行为有独特的关联，并表明这些关联可能因酒精相关攻击事件的类型和频率而异。(PsycInfo Database Record (c) 2024 APA，保留所有权利）。
Genetic risk for trait aggression and alcohol use predict unique facets of alcohol-related aggression.
Objective: A propensity for aggression or alcohol use may be associated with alcohol-related aggression. Previous research has shown genetic overlap between alcohol use and aggression but has not looked at how alcohol-related aggression may be uniquely influenced by genetic risk for aggression or alcohol use. The present study examined the associations of genetic risk for trait aggression, alcohol use, and alcohol use disorder (AUD) with alcohol-related aggression using a polygenic risk score (PRS) approach.
Method: Using genome-wide association study summary statistics, PRSs were created for trait aggression, alcohol consumption, and AUD. These PRSs were used to predict the phenotype of alcohol-related aggression among drinkers in two independent samples: the University of California at San Francisco (UCSF) Family Alcoholism Study (n = 1,162) and the National Longitudinal Study of Adolescent to Adult Health (Add Health; n = 4,291).
Results: There were significant associations between the AUD PRS and lifetime alcohol-related aggression in the UCSF study sample. Additionally, the trait aggression PRS was associated with three or more experiences of hitting anyone else and getting into physical fights while under the influence of alcohol, along with a composite score of three or more experiences of alcohol-related aggression, in the UCSF study sample. No significant associations were observed in the Add Health sample. Limited sex-specific genetic effects were observed.
Conclusions: These results provide preliminary evidence that genetic influences underlying alcohol use and aggression are uniquely associated with alcohol-related aggression and suggest that these associations may differ by type and frequency of alcohol-related aggression incidents. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
期刊介绍：
Psychology of Addictive Behaviors publishes peer-reviewed original articles related to the psychological aspects of addictive behaviors. The journal includes articles on the following topics: - alcohol and alcoholism - drug use and abuse - eating disorders - smoking and nicotine addiction, and other excessive behaviors (e.g., gambling) Full-length research reports, literature reviews, brief reports, and comments are published.
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