Salvatore Siracusano, Paolo Gontero, Ettore Mearini, Ciro Imbimbo, Alchiede Simonato, Fabrizio Dal Moro, Gianluca Giannarini, Francesco Montorsi, Renzo Colombo, Francesco Porpiglia, Riccardo Bartoletti, Andrea Minervini, Marta Rossanese, Antonio Porcaro, Federico Romantini, Igino A Magli, Savio D Pandolfo, Renato Talamini, Marco Racioppi, Vincenzo Ficarra, Cristina Lonardi
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Baseline characteristics, including demographic profile, BMI, Charlson Comorbidity Index (CCI), modified Frailty Index (m-FI), pathological tumor stage, Clavien-Dindo grade, and neo-adjuvant chemotherapy were recorded and compared.</p><p><strong>Results: </strong>The uni-variate and multivariate analysis (OR) were performed for constipation, diarrhea and m-FI of patients underwent RC for localized MIBC according to global health status score (poor/good vs. very good). Multivariate analysis showed that constipation medium/high was significant associated with global health status poor/good (OR=2.39; 95% CI: 1.22-4.71; P=0.01); Diarrhea medium/high was associated with global health status poor/good (OR=2.85; 95% CI:1.18-6.92; P=0.02), and m-FI ≥2 score (OR=2.13; 95% CI: 0.99-4.57; P=0.05).</p><p><strong>Conclusions: </strong>Diarrhea and constipation are associated with a lower QoL in cystectomized patients, both with ONB or IC urinary diversion; such association is especially significant in more fragile patients (Frailty Index ≥2).</p>","PeriodicalId":53228,"journal":{"name":"Minerva Urology and Nephrology","volume":" ","pages":"452-457"},"PeriodicalIF":4.9000,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Short-term effects of bowel function on global health quality of life after radical cystectomy.\",\"authors\":\"Salvatore Siracusano, Paolo Gontero, Ettore Mearini, Ciro Imbimbo, Alchiede Simonato, Fabrizio Dal Moro, Gianluca Giannarini, Francesco Montorsi, Renzo Colombo, Francesco Porpiglia, Riccardo Bartoletti, Andrea Minervini, Marta Rossanese, Antonio Porcaro, Federico Romantini, Igino A Magli, Savio D Pandolfo, Renato Talamini, Marco Racioppi, Vincenzo Ficarra, Cristina Lonardi\",\"doi\":\"10.23736/S2724-6051.24.05730-6\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Radical cystectomy (RC) shows an important impact on quality of life (QoL), for various clinical aspects. 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Multivariate analysis showed that constipation medium/high was significant associated with global health status poor/good (OR=2.39; 95% CI: 1.22-4.71; P=0.01); Diarrhea medium/high was associated with global health status poor/good (OR=2.85; 95% CI:1.18-6.92; P=0.02), and m-FI ≥2 score (OR=2.13; 95% CI: 0.99-4.57; P=0.05).</p><p><strong>Conclusions: </strong>Diarrhea and constipation are associated with a lower QoL in cystectomized patients, both with ONB or IC urinary diversion; such association is especially significant in more fragile patients (Frailty Index ≥2).</p>\",\"PeriodicalId\":53228,\"journal\":{\"name\":\"Minerva Urology and Nephrology\",\"volume\":\" \",\"pages\":\"452-457\"},\"PeriodicalIF\":4.9000,\"publicationDate\":\"2024-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Minerva Urology and Nephrology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.23736/S2724-6051.24.05730-6\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/6/5 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"UROLOGY & NEPHROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Minerva Urology and Nephrology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.23736/S2724-6051.24.05730-6","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/6/5 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"UROLOGY & NEPHROLOGY","Score":null,"Total":0}
引用次数: 0
摘要
背景：根治性膀胱切除术（RC）对生活质量（QoL）有重要影响，涉及多个临床方面。我们的研究旨在评估接受根治性膀胱切除术患者的短期肠道功能：方法：260 名宫颈癌患者接受了 RC 和 ONB 或 IC 尿路转流术。在术前和术后 12 个月，使用 EORTC QLQ C30 和短表 SF-36 问卷对患者的 QoL 进行测量。记录并比较了基线特征，包括人口统计学特征、体重指数（BMI）、查尔森综合指数（CCI）、改良虚弱指数（m-FI）、肿瘤病理分期、克拉维恩-丁多分级和新辅助化疗：根据总体健康状况评分（差/好 vs 很好），对接受局部 MIBC RC 治疗的患者的便秘、腹泻和 m-FI 进行了单变量和多变量分析（OR）。多变量分析显示，便秘中度/高度与总体健康状况差/好显著相关（OR=2.39；95% CI：1.22-4.71；P=0.01）；腹泻中度/高度与总体健康状况差/好相关（OR=2.85；95% CI：1.18-6.92；P=0.02），与 m-FI ≥2分相关（OR=2.13；95% CI：0.99-4.57；P=0.05）：腹泻和便秘与膀胱切除术（ONB或IC尿流改道）患者较低的生活质量相关；这种关联在较脆弱的患者（虚弱指数≥2）中尤为显著。
Short-term effects of bowel function on global health quality of life after radical cystectomy.
Background: Radical cystectomy (RC) shows an important impact on quality of life (QoL), for various clinical aspects. The aim of our study was to evaluate the short-term bowel function in patients that underwent RC.
Methods: Two hundred and six patients with MIBC underwent RC with ONB or IC urinary diversion. QoL was measured using the EORTC QLQ C30 and the Short-Form SF-36 questionnaires before surgery and at 12 months postoperatively. Baseline characteristics, including demographic profile, BMI, Charlson Comorbidity Index (CCI), modified Frailty Index (m-FI), pathological tumor stage, Clavien-Dindo grade, and neo-adjuvant chemotherapy were recorded and compared.
Results: The uni-variate and multivariate analysis (OR) were performed for constipation, diarrhea and m-FI of patients underwent RC for localized MIBC according to global health status score (poor/good vs. very good). Multivariate analysis showed that constipation medium/high was significant associated with global health status poor/good (OR=2.39; 95% CI: 1.22-4.71; P=0.01); Diarrhea medium/high was associated with global health status poor/good (OR=2.85; 95% CI:1.18-6.92; P=0.02), and m-FI ≥2 score (OR=2.13; 95% CI: 0.99-4.57; P=0.05).
Conclusions: Diarrhea and constipation are associated with a lower QoL in cystectomized patients, both with ONB or IC urinary diversion; such association is especially significant in more fragile patients (Frailty Index ≥2).
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