Ronney B Panerai, Abdulaziz Alshehri, Lucy C Beishon, Aaron Davies, Victoria J Haunton, Emmanuel Katsogridakis, Man Y Lam, Osian Llwyd, Thompson G Robinson, Jatinder S Minhas
{"title":"大脑临界关闭压对平均动脉压变化的动态响应的决定因素。","authors":"Ronney B Panerai, Abdulaziz Alshehri, Lucy C Beishon, Aaron Davies, Victoria J Haunton, Emmanuel Katsogridakis, Man Y Lam, Osian Llwyd, Thompson G Robinson, Jatinder S Minhas","doi":"10.1088/1361-6579/ad548d","DOIUrl":null,"url":null,"abstract":"<p><p><i>Objective</i>. Cerebral critical closing pressure (CrCP) represents the value of arterial blood pressure (BP) where cerebral blood flow (CBF) becomes zero. Its dynamic response to a step change in mean BP (MAP) has been shown to reflect CBF autoregulation, but robust methods for its estimation are lacking. We aim to improve the quality of estimates of the CrCP dynamic response.<i>Approach</i>. Retrospective analysis of 437 healthy subjects (aged 18-87 years, 218 males) baseline recordings with measurements of cerebral blood velocity in the middle cerebral artery (MCAv, transcranial Doppler), non-invasive arterial BP (Finometer) and end-tidal CO<sub>2</sub>(EtCO<sub>2</sub>, capnography). For each cardiac cycle CrCP was estimated from the instantaneous MCAv-BP relationship. Transfer function analysis of the MAP and MCAv (MAP-MCAv) and CrCP (MAP-CrCP) allowed estimation of the corresponding step responses (SR) to changes in MAP, with the output in MCAv (SRV<sub>MCAv</sub>) representing the autoregulation index (ARI), ranging from 0 to 9. Four main parameters were considered as potential determinants of the SRV<sub>CrCP</sub>temporal pattern, including the coherence function, MAP spectral power and the reconstruction error for SRV<sub>MAP</sub>, from the other three separate SRs.<i>Main results</i>. The reconstruction error for SRV<sub>MAP</sub>was the main determinant of SRV<sub>CrCP</sub>signal quality, by removing the largest number of outliers (Grubbs test) compared to the other three parameters. SRV<sub>CrCP</sub>showed highly significant (<i>p</i>< 0.001) changes with time, but its amplitude or temporal pattern was not influenced by sex or age. The main physiological determinants of SRV<sub>CrCP</sub>were the ARI and the mean CrCP for the entire 5 min baseline period. The early phase (2-3 s) of SRV<sub>CrCP</sub>response was influenced by heart rate whereas the late phase (10-14 s) was influenced by diastolic BP.<i>Significance</i>. These results should allow better planning and quality of future research and clinical trials of novel metrics of CBF regulation.</p>","PeriodicalId":20047,"journal":{"name":"Physiological measurement","volume":" ","pages":""},"PeriodicalIF":2.3000,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Determinants of the dynamic cerebral critical closing pressure response to changes in mean arterial pressure.\",\"authors\":\"Ronney B Panerai, Abdulaziz Alshehri, Lucy C Beishon, Aaron Davies, Victoria J Haunton, Emmanuel Katsogridakis, Man Y Lam, Osian Llwyd, Thompson G Robinson, Jatinder S Minhas\",\"doi\":\"10.1088/1361-6579/ad548d\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><i>Objective</i>. Cerebral critical closing pressure (CrCP) represents the value of arterial blood pressure (BP) where cerebral blood flow (CBF) becomes zero. Its dynamic response to a step change in mean BP (MAP) has been shown to reflect CBF autoregulation, but robust methods for its estimation are lacking. We aim to improve the quality of estimates of the CrCP dynamic response.<i>Approach</i>. Retrospective analysis of 437 healthy subjects (aged 18-87 years, 218 males) baseline recordings with measurements of cerebral blood velocity in the middle cerebral artery (MCAv, transcranial Doppler), non-invasive arterial BP (Finometer) and end-tidal CO<sub>2</sub>(EtCO<sub>2</sub>, capnography). For each cardiac cycle CrCP was estimated from the instantaneous MCAv-BP relationship. Transfer function analysis of the MAP and MCAv (MAP-MCAv) and CrCP (MAP-CrCP) allowed estimation of the corresponding step responses (SR) to changes in MAP, with the output in MCAv (SRV<sub>MCAv</sub>) representing the autoregulation index (ARI), ranging from 0 to 9. Four main parameters were considered as potential determinants of the SRV<sub>CrCP</sub>temporal pattern, including the coherence function, MAP spectral power and the reconstruction error for SRV<sub>MAP</sub>, from the other three separate SRs.<i>Main results</i>. The reconstruction error for SRV<sub>MAP</sub>was the main determinant of SRV<sub>CrCP</sub>signal quality, by removing the largest number of outliers (Grubbs test) compared to the other three parameters. SRV<sub>CrCP</sub>showed highly significant (<i>p</i>< 0.001) changes with time, but its amplitude or temporal pattern was not influenced by sex or age. The main physiological determinants of SRV<sub>CrCP</sub>were the ARI and the mean CrCP for the entire 5 min baseline period. The early phase (2-3 s) of SRV<sub>CrCP</sub>response was influenced by heart rate whereas the late phase (10-14 s) was influenced by diastolic BP.<i>Significance</i>. These results should allow better planning and quality of future research and clinical trials of novel metrics of CBF regulation.</p>\",\"PeriodicalId\":20047,\"journal\":{\"name\":\"Physiological measurement\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.3000,\"publicationDate\":\"2024-06-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Physiological measurement\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/10.1088/1361-6579/ad548d\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"BIOPHYSICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Physiological measurement","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1088/1361-6579/ad548d","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOPHYSICS","Score":null,"Total":0}
Determinants of the dynamic cerebral critical closing pressure response to changes in mean arterial pressure.
Objective. Cerebral critical closing pressure (CrCP) represents the value of arterial blood pressure (BP) where cerebral blood flow (CBF) becomes zero. Its dynamic response to a step change in mean BP (MAP) has been shown to reflect CBF autoregulation, but robust methods for its estimation are lacking. We aim to improve the quality of estimates of the CrCP dynamic response.Approach. Retrospective analysis of 437 healthy subjects (aged 18-87 years, 218 males) baseline recordings with measurements of cerebral blood velocity in the middle cerebral artery (MCAv, transcranial Doppler), non-invasive arterial BP (Finometer) and end-tidal CO2(EtCO2, capnography). For each cardiac cycle CrCP was estimated from the instantaneous MCAv-BP relationship. Transfer function analysis of the MAP and MCAv (MAP-MCAv) and CrCP (MAP-CrCP) allowed estimation of the corresponding step responses (SR) to changes in MAP, with the output in MCAv (SRVMCAv) representing the autoregulation index (ARI), ranging from 0 to 9. Four main parameters were considered as potential determinants of the SRVCrCPtemporal pattern, including the coherence function, MAP spectral power and the reconstruction error for SRVMAP, from the other three separate SRs.Main results. The reconstruction error for SRVMAPwas the main determinant of SRVCrCPsignal quality, by removing the largest number of outliers (Grubbs test) compared to the other three parameters. SRVCrCPshowed highly significant (p< 0.001) changes with time, but its amplitude or temporal pattern was not influenced by sex or age. The main physiological determinants of SRVCrCPwere the ARI and the mean CrCP for the entire 5 min baseline period. The early phase (2-3 s) of SRVCrCPresponse was influenced by heart rate whereas the late phase (10-14 s) was influenced by diastolic BP.Significance. These results should allow better planning and quality of future research and clinical trials of novel metrics of CBF regulation.
期刊介绍：
Physiological Measurement publishes papers about the quantitative assessment and visualization of physiological function in clinical research and practice, with an emphasis on the development of new methods of measurement and their validation.
Papers are published on topics including:
applied physiology in illness and health
electrical bioimpedance, optical and acoustic measurement techniques
advanced methods of time series and other data analysis
biomedical and clinical engineering
in-patient and ambulatory monitoring
point-of-care technologies
novel clinical measurements of cardiovascular, neurological, and musculoskeletal systems.
measurements in molecular, cellular and organ physiology and electrophysiology
physiological modeling and simulation
novel biomedical sensors, instruments, devices and systems
measurement standards and guidelines.
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