通过硝基烯的非催化异狄尔斯-阿尔德反应合成 1,2-恶嗪 N-氧化物（微型综述）

IF 1.4 4区化学 Q3 CHEMISTRY, ORGANIC

Chemistry of Heterocyclic Compounds Pub Date : 2024-06-03 DOI:10.1007/s10593-024-03304-4

Radomir Jasiński

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引用次数: 0

摘要

在这篇微综述中，根据最近发表的文章，综述了共轭硝基烯及其类似物参与的非催化异狄尔斯-阿尔德反应（正式的 [4+2] 环化反应）在简便、选择性地制备 1,2-恶嗪 N-氧化物方面的应用。研究发现，所描述的最佳工艺都能在温和的温度下实现完全的区域选择性。有趣的是，在某些标题反应中，形成六元杂环的分步机理比经典的一步机理更有可能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Synthesis of 1,2-oxazine N-oxides via noncatalyzed hetero-Diels–Alder reactions of nitroalkenes (microreview)

In this microreview, the application of noncatalyzed hetero-Diels–Alder reaction (formally [4+2] cycloaddition) with participation of conjugated nitroalkenes and their analogs for easy and selective preparation of 1,2-oxazine N-oxides was reviewed on the basis of recent publications. It was found that the best described processes are realized with full regioselectivity as well as at mild temperatures. It is interesting, that in some cases of the title reactions, the stepwise mechanism of the formation of the six-membered heterocyclic ring is more possible than classic one-step mechanism.

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来源期刊

Chemistry of Heterocyclic Compounds 化学-有机化学

CiteScore

2.90

自引率

13.30%

发文量

审稿时长

1 months

期刊介绍： The international journal Chemistry of Heterocyclic Compounds publishes original papers, short communications, reviews, and mini-reviews dealing with problems in the field of heterocyclic chemistry in Russian and English. The Journal also publishes reviews and annotations on new books and brief reports on conferences in the field of heterocyclic chemistry, as well as commemoratives dedicated to prominent heterocyclic chemists.