高效去除生物气溶胶的协同化学机械抗菌可穿刺纳米结构

IF 5.5 3区 工程技术 Q1 BIOCHEMICAL RESEARCH METHODS
Kyeong Seok Kim, Inae Lee, Joonseok Lee
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引用次数: 0

摘要

人们对空气污染和生物气溶胶引起的传染病风险的担忧,导致对有效过滤解决方案的需求不断增长。有效捕捉生物气溶胶至关重要,然而,解决捕捉到的气溶胶在空气过滤器上随着时间推移可能繁殖的问题也至关重要。因此,为了防止生物气溶胶的扩散,确保空气过滤系统更安全、更健康,开发具有增强抗菌保护功能的空气过滤器势在必行。在本研究中,抗菌肽共轭纳米结构被用于通过协同化学机械抗菌作用来增强对生物气溶胶的捕获和杀灭。我们在空气过滤器上设计了一种可穿刺的纳米结构,并用抗菌肽 LL-37 对其进行了功能化处理。我们进行了生物气溶胶过滤和抗菌性能测试,以评估抗菌可穿刺纳米结构对去除生物气溶胶的协同作用。多肽共轭的可穿刺纳米结构空气过滤器在生物气溶胶捕获方面优于裸露的空气过滤器,而且对生物气溶胶的接触杀灭性能明显更好。这些特性表明,该过滤器能够显著捕获和杀灭空气中的病原体。协同化学-机械-抗微生物纳米结构过滤器在应对空气传播威胁方面大有可为,是一种安全的过滤解决方案,不存在生物毒性问题,适合在市场上广泛使用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Synergetic Chemo-Mechano Antimicrobial Puncturable Nanostructures for Efficient Bioaerosol Removal

Synergetic Chemo-Mechano Antimicrobial Puncturable Nanostructures for Efficient Bioaerosol Removal

Concerns regarding air pollution and the risk of infectious diseases caused by bioaerosols have led to growing demand for effective filtration solutions. The effective capture of bioaerosols is essential; however, addressing the potential multiplication of captured aerosols on the air filter over time is also crucial. Therefore, the development of air filters with enhanced antimicrobial protection is imperative for preventing the proliferation of bioaerosols and ensuring safer and healthier air filtration systems. In this study, antimicrobial peptides conjugated nanostructures were used to enhance the capture and killing of bioaerosols with synergistic chemo-mechano-antimicrobial actions. We designed a puncturable nanostructure on an air filter and functionalized it with the antimicrobial LL-37 peptide. Bioaerosol filtration and antimicrobial performance tests were conducted to evaluate the synergistic effects of the antimicrobial puncturable nanostructures on bioaerosol removal. The peptide-conjugated puncturable nanostructured air filter outperformed bare air filters in bioaerosol capture and exhibited significantly better contact-killing properties against bioaerosols. These attributes indicate the ability of the filter to significant capture and kill airborne pathogens. The synergetic chemo-mechano-antimicrobial nanostructured filter is promising for combating airborne threats and serves as a safe filtration solution that is free from biotoxicity concerns and is suitable for widespread implementation in the market.

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来源期刊
BioChip Journal
BioChip Journal 生物-生化研究方法
CiteScore
7.70
自引率
16.30%
发文量
47
审稿时长
6-12 weeks
期刊介绍: BioChip Journal publishes original research and reviews in all areas of the biochip technology in the following disciplines, including protein chip, DNA chip, cell chip, lab-on-a-chip, bio-MEMS, biosensor, micro/nano mechanics, microfluidics, high-throughput screening technology, medical science, genomics, proteomics, bioinformatics, medical diagnostics, environmental monitoring and micro/nanotechnology. The Journal is committed to rapid peer review to ensure the publication of highest quality original research and timely news and review articles.
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