合成 Hoechst 33258 的双苯并恶唑类似物作为潜在的 GC 选择性 DNA 配体

IF 1.5 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Biology Pub Date : 2024-06-05 DOI:10.1134/s0026893324700171

A. F. Arutuynyan, M. S. Aksenova, A. A. Kostyukov, A. A. Stomakhin, D. N. Kaluzhny, A. L. Zhuze

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引用次数: 0

摘要

摘要利用计算机建模方法，我们提出了一种潜在的 GC 特异性 DNA 配体的结构，这种配体可与 DNA 在小沟中形成复合物，类似于 Hoechst 33258 在 DNA AT 富集位点上形成的复合物。根据这一模型，合成了双苯并恶唑配体 MBoz2A。分光光度法的结果表明，所研究的化合物与核苷酸组成不同的 DNA 形成了复合物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Synthesis of a Bisbenzoxazole Analogue of Hoechst 33258 as a Potential GC-Selective DNA Ligand

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Synthesis of a Bisbenzoxazole Analogue of Hoechst 33258 as a Potential GC-Selective DNA Ligand

Abstract

Using a computer modeling approach, we proposed a structure for a potential GC-specific DNA ligand, which could form a complex with DNA in the minor groove similar to that formed by Hoechst 33258 at DNA AT-enriched sites. According to this model, MBoz₂A, a bisbenzoxazole ligand, was synthesized. The results of spectrophotometric methods supported the complex formation of the compound under study with DNA differing in the nucleotide composition.

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来源期刊

Molecular Biology 生物-生化与分子生物学

CiteScore

1.30

自引率

8.30%

发文量

审稿时长

3 months

期刊介绍： Molecular Biology is an international peer reviewed journal that covers a wide scope of problems in molecular, cell and computational biology including genomics, proteomics, bioinformatics, molecular virology and immunology, molecular development biology, molecular evolution and related areals. Molecular Biology publishes reviews, experimental and theoretical works. Every year, the journal publishes special issues devoted to most rapidly developing branches of physical-chemical biology and to the most outstanding scientists.