A. S. Lozhkomoev, S. O. Kazantsev, O. V. Bakina, A. S. Buyakov, E. I. Senkina, M. G. Krinitcyn, V. A. Ivanyuk, A. F. Sharipova, M. I. Lerner
{"title":"制备具有基于聚乳酸和万古霉素的抗菌涂层的铁基支架","authors":"A. S. Lozhkomoev, S. O. Kazantsev, O. V. Bakina, A. S. Buyakov, E. I. Senkina, M. G. Krinitcyn, V. A. Ivanyuk, A. F. Sharipova, M. I. Lerner","doi":"10.1134/s207511332470028x","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract—</h3><p>A method for obtaining iron scaffolds with porosity of about 70% with the use of a Fe nanopowder with an average size of 68 ± 2 nm and modified with vancomycin to impart antibacterial properties to the material is described. Studies of the structure and composition of the scaffolds and mechanical characteristics that demonstrate high values of the ultimate strength of the samples (about 15 MPa) are carried out. The modification of the surface of the scaffolds with polylactic acid leads to an increase in the ultimate strength by 40% and overall smoothing of the stress–strain curve. It is shown that the introduction of vancomycin into the polymer makes it possible to obtain an antibacterial coating on the surface of the scaffold with prolonged release of the medicinal product.</p>","PeriodicalId":586,"journal":{"name":"Inorganic Materials: Applied Research","volume":null,"pages":null},"PeriodicalIF":0.5000,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The Preparation of Iron-Based Scaffolds with an Antibacterial Coating Based on Polylactic Acid and Vancomycin\",\"authors\":\"A. S. Lozhkomoev, S. O. Kazantsev, O. V. Bakina, A. S. Buyakov, E. I. Senkina, M. G. Krinitcyn, V. A. Ivanyuk, A. F. Sharipova, M. I. Lerner\",\"doi\":\"10.1134/s207511332470028x\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<h3 data-test=\\\"abstract-sub-heading\\\">Abstract—</h3><p>A method for obtaining iron scaffolds with porosity of about 70% with the use of a Fe nanopowder with an average size of 68 ± 2 nm and modified with vancomycin to impart antibacterial properties to the material is described. Studies of the structure and composition of the scaffolds and mechanical characteristics that demonstrate high values of the ultimate strength of the samples (about 15 MPa) are carried out. The modification of the surface of the scaffolds with polylactic acid leads to an increase in the ultimate strength by 40% and overall smoothing of the stress–strain curve. It is shown that the introduction of vancomycin into the polymer makes it possible to obtain an antibacterial coating on the surface of the scaffold with prolonged release of the medicinal product.</p>\",\"PeriodicalId\":586,\"journal\":{\"name\":\"Inorganic Materials: Applied Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.5000,\"publicationDate\":\"2024-06-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Inorganic Materials: Applied Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1134/s207511332470028x\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"MATERIALS SCIENCE, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Inorganic Materials: Applied Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1134/s207511332470028x","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
The Preparation of Iron-Based Scaffolds with an Antibacterial Coating Based on Polylactic Acid and Vancomycin
Abstract—
A method for obtaining iron scaffolds with porosity of about 70% with the use of a Fe nanopowder with an average size of 68 ± 2 nm and modified with vancomycin to impart antibacterial properties to the material is described. Studies of the structure and composition of the scaffolds and mechanical characteristics that demonstrate high values of the ultimate strength of the samples (about 15 MPa) are carried out. The modification of the surface of the scaffolds with polylactic acid leads to an increase in the ultimate strength by 40% and overall smoothing of the stress–strain curve. It is shown that the introduction of vancomycin into the polymer makes it possible to obtain an antibacterial coating on the surface of the scaffold with prolonged release of the medicinal product.
期刊介绍：
Inorganic Materials: Applied Research contains translations of research articles devoted to applied aspects of inorganic materials. Best articles are selected from four Russian periodicals: Materialovedenie, Perspektivnye Materialy, Fizika i Khimiya Obrabotki Materialov, and Voprosy Materialovedeniya and translated into English. The journal reports recent achievements in materials science: physical and chemical bases of materials science; effects of synergism in composite materials; computer simulations; creation of new materials (including carbon-based materials and ceramics, semiconductors, superconductors, composite materials, polymers, materials for nuclear engineering, materials for aircraft and space engineering, materials for quantum electronics, materials for electronics and optoelectronics, materials for nuclear and thermonuclear power engineering, radiation-hardened materials, materials for use in medicine, etc.); analytical techniques; structure–property relationships; nanostructures and nanotechnologies; advanced technologies; use of hydrogen in structural materials; and economic and environmental issues. The journal also considers engineering issues of materials processing with plasma, high-gradient crystallization, laser technology, and ultrasonic technology. Currently the journal does not accept direct submissions, but submissions to one of the source journals is possible.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
