从新诊断前列腺癌患者的早期和标准时间 68Ga-PSMA PET/CT 图像中得出的前列腺内体积参数的预测意义。

IF 1.3 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Nuclear Medicine Communications Pub Date : 2024-07-01 Epub Date: 2024-04-27 DOI:10.1097/MNM.0000000000001851
Ezgi Basak Erdogan, Ertugrul Tekce, Serhat Koca, Nesrin Aslan, Ozlem Toluk, Mehmet Aydin
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引用次数: 0

摘要

目的研究未经治疗的前列腺癌(PCa)患者早期盆腔和标准时间全身68Ga-PSMA PET/计算机断层扫描(CT)图像中前列腺内68Ga-前列腺特异性膜抗原(PSMA)摄取值与容积参数之间的关系,并评估这些数据与疾病预后的预测意义,同时与68Ga-PSMA PET/CT成像中检测到的格里森评分、临床风险分级和是否存在转移性疾病进行比较:方法:81 名新确诊的 PCa 患者在第 5 分钟时接受早期盆腔成像,在第 60 分钟时接受标准时间全身成像。在前列腺内划线时使用了不同的阈值来计算最大标准化摄取值(SUVmax)、平均标准化摄取值(SUVmean)、前列腺内PSMA肿瘤体积和前列腺内病变总PSMA摄取量。研究了早期测量值与标准时间测量值之间的相关性,以及 SUV 参数随时间的变化。研究还探讨了这些值与格里森评分、临床风险状况(美国国家综合癌症网络)和转移性疾病的关系:结果:早期和标准时间图像的 SUVmax 测量值区分了所有三个组别(临床风险评分、Gleason 评分和转移组),标准成像在接收者操作特征分析中显示出统计学优势。早期和标准时间 PET 参数之间存在很强的相关性。睾丸内SUVmax和SUVmean值随时间的变化并不具有预测价值:尽管早期和标准时间的睾丸内PSMA PET参数基本一致,但在新诊断的未经治疗的PCa患者中,标准时间图像获得的参数与临床风险评分、Gleason评分和转移状态的相关性更强。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Predictive significance of intraprostatic volumetric parameters derived from early and standard time 68Ga-PSMA PET/CT images in newly diagnosed prostate cancer patients.

Objective: To investigate the relationship between intraprostatic 68Ga-prostate-specific membrane antigen (PSMA) uptake values and volumetric parameters derived from early pelvic and standard-time whole-body 68Ga-PSMA PET/computed tomography (CT) images in untreated prostate cancer (PCa) patients, and to assess the predictive significance of these data in relation to disease prognosis, comparing them with the Gleason score, clinical risk classification and the presence of metastatic disease detected in 68Ga-PSMA PET/CT imaging.

Methods: Eighty-one newly diagnosed PCa patients underwent early phase pelvic imaging at the 5th minute and standard time whole-body imaging at the 60th minute. Various threshold values were used in intraprostatic delineations to compute maximum standardized uptake value (SUVmax), mean standardized uptake value (SUVmean), intraprostatic PSMA tumor volume and intraprostatic total lesion PSMA uptake. Correlations between early and standard time measurements, as well as changes in SUV parameters over time, were examined. The association of these values with Gleason score, clinical risk status (National Comprehensive Cancer Network), and metastatic disease was explored.

Results: SUVmax measurements from both early and standard time images distinguished all three groups (clinical risk scores, Gleason score and metastatic group), with standard imaging demonstrating statistical superiority in receiver operating characteristic analyses. Strong correlations were observed between early and standard-time PET parameters. Changes in intraprostatic SUVmax and SUVmean values over time did not exhibit predictive value.

Conclusion: Although intraprostatic PSMA PET parameters generally aligned at both early and standard times, parameters obtained from standard time images showed more robust correlations with clinical risk scores, Gleason score and metastasis status in newly diagnosed, untreated PCa patients.

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来源期刊
CiteScore
2.20
自引率
6.70%
发文量
212
审稿时长
3-8 weeks
期刊介绍: Nuclear Medicine Communications, the official journal of the British Nuclear Medicine Society, is a rapid communications journal covering nuclear medicine and molecular imaging with radionuclides, and the basic supporting sciences. As well as clinical research and commentary, manuscripts describing research on preclinical and basic sciences (radiochemistry, radiopharmacy, radiobiology, radiopharmacology, medical physics, computing and engineering, and technical and nursing professions involved in delivering nuclear medicine services) are welcomed, as the journal is intended to be of interest internationally to all members of the many medical and non-medical disciplines involved in nuclear medicine. In addition to papers reporting original studies, frankly written editorials and topical reviews are a regular feature of the journal.
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