N C Harvey, K A Ward, D Agnusdei, N Binkley, E Biver, C Campusano, E Cavalier, P Clark, M Diaz-Curiel, G E-H Fuleihan, P Khashayar, N E Lane, O D Messina, A Mithal, R Rizzoli, C Sempos, B Dawson-Hughes
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引用次数: 0
摘要
维生素 D 对肌肉骨骼健康非常重要。25- 羟基维生素 D 是最常测量的代谢物,其浓度在世界各地有明显差异,并受许多因素的影响,包括阳光照射、皮肤色素沉着、覆盖物、季节和补充剂的使用。明显缺乏维生素 D 会导致生化后果,增加发生佝偻病、骨软化症或心肌病等严重后遗症的风险,通常需要及时进行补充治疗。这里的问题是要使人口的平均水平保持在一定水平上,从而最大限度地降低人口中出现不良健康后果的风险。本立场文件是对欧洲骨质疏松症、骨关节炎和肌肉骨骼疾病临床与经济学会最近发表的研究成果的补充,从人群的角度阐述了维生素 D 评估和干预的主要考虑因素。这份立场文件代表国际骨质疏松症基金会维生素 D 工作组,总结了全球人口维生素 D 缺乏的负担和可能的改善措施。它探讨了包括筛查、补充和食物强化在内的关键问题。
Optimisation of vitamin D status in global populations.
Vitamin D is important for musculoskeletal health. Concentrations of 25-hydroxyvitamin D, the most commonly measured metabolite, vary markedly around the world and are influenced by many factors including sun exposure, skin pigmentation, covering, season and supplement use. Whilst overt vitamin D deficiency with biochemical consequences presents an increased risk of severe sequelae such as rickets, osteomalacia or cardiomyopathy and usually warrants prompt replacement treatment, the role of vitamin D supplementation in the population presents a different set of considerations. Here the issue is to keep, on average, the population at a level whereby the risk of adverse health outcomes in the population is minimised. This position paper, which complements recently published work from the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases, addresses key considerations regarding vitamin D assessment and intervention from the population perspective. This position paper, on behalf of the International Osteoporosis Foundation Vitamin D Working Group, summarises the burden and possible amelioration of vitamin D deficiency in global populations. It addresses key issues including screening, supplementation and food fortification.
期刊介绍:
An international multi-disciplinary journal which is a joint initiative between the International Osteoporosis Foundation and the National Osteoporosis Foundation of the USA, Osteoporosis International provides a forum for the communication and exchange of current ideas concerning the diagnosis, prevention, treatment and management of osteoporosis and other metabolic bone diseases.
It publishes: original papers - reporting progress and results in all areas of osteoporosis and its related fields; review articles - reflecting the present state of knowledge in special areas of summarizing limited themes in which discussion has led to clearly defined conclusions; educational articles - giving information on the progress of a topic of particular interest; case reports - of uncommon or interesting presentations of the condition.
While focusing on clinical research, the Journal will also accept submissions on more basic aspects of research, where they are considered by the editors to be relevant to the human disease spectrum.