[类风湿性关节炎女性患者的骨质密度：免疫和生化指标之间的联系]。

Pub Date : 2024-06-03 DOI:10.26442/00403660.2024.05.202705

O V Dobrovolskaya, N V Demin, M V Kozyreva, E Y Samarkina, M E Diatroptov, N V Toroptsova

{"title":"[类风湿性关节炎女性患者的骨质密度：免疫和生化指标之间的联系]。","authors":"O V Dobrovolskaya, N V Demin, M V Kozyreva, E Y Samarkina, M E Diatroptov, N V Toroptsova","doi":"10.26442/00403660.2024.05.202705","DOIUrl":null,"url":null,"abstract":"Aim: To study the association of bone mineral density (BMD) with serum biochemical and immunological markers in postmenopausal women with rheumatoid arthritis (RA).Materials and methods: The study included 173 women with RA (age 61.0 [56.0; 66.0] years). A survey, dual-energy X-ray absorptiometry to measure the BMD of the lumbar spine (LI-LIV), femoral neck (FN) and total hip (TH), routine blood chemistry, measurement of C-reactive protein (CRP), rheumatoid factor, cyclic citrullinated peptide antibodies (CCPA), parathyroid hormone (PTH), vitamin D3, myostatin, follistatin, interleukin-6 (IL-6), IL-6 receptors, insulin-like growth factor 1, adiponectin, leptin, fibroblast growth factor 23, and tumor necrosis factor SF12 were performed.Results: PTH (β=-0.22, -0.35 and -0.30 for LI-LIV, FN and TH, respectively), CRP (β=-0.18, 0.23 and -0.22 for LI-LIV, FN and TH, respectively) and leptin (β=0.35, 0.32 and 0.42 for LI-LIV, FN and TH, respectively) were shown a significant association with BMD in all sites of measurement. It was independent of age, body mass index and postmenopause duration. Associations were also found between adiponectin and BMD of LI-LIV and TH (β=-0.36 and -0.28, respectively), CCPA and BMD of FN and TH (β=-0.21, -0.24, respectively) and IL-6 and BMD of FN (β=0.37).Conclusion: The study of biochemical and immunological markers in women with RA demonstrated that CRP, CCPA, PTH, IL-6, adiponectin, and leptin influenced BMD.","PeriodicalId":0,"journal":{"name":"","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[Bone mineral density in women with rheumatoid arthritis: A link between immune and biochemical markers].\",\"authors\":\"O V Dobrovolskaya, N V Demin, M V Kozyreva, E Y Samarkina, M E Diatroptov, N V Toroptsova\",\"doi\":\"10.26442/00403660.2024.05.202705\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Aim: To study the association of bone mineral density (BMD) with serum biochemical and immunological markers in postmenopausal women with rheumatoid arthritis (RA).Materials and methods: The study included 173 women with RA (age 61.0 [56.0; 66.0] years). A survey, dual-energy X-ray absorptiometry to measure the BMD of the lumbar spine (LI-LIV), femoral neck (FN) and total hip (TH), routine blood chemistry, measurement of C-reactive protein (CRP), rheumatoid factor, cyclic citrullinated peptide antibodies (CCPA), parathyroid hormone (PTH), vitamin D3, myostatin, follistatin, interleukin-6 (IL-6), IL-6 receptors, insulin-like growth factor 1, adiponectin, leptin, fibroblast growth factor 23, and tumor necrosis factor SF12 were performed.Results: PTH (β=-0.22, -0.35 and -0.30 for LI-LIV, FN and TH, respectively), CRP (β=-0.18, 0.23 and -0.22 for LI-LIV, FN and TH, respectively) and leptin (β=0.35, 0.32 and 0.42 for LI-LIV, FN and TH, respectively) were shown a significant association with BMD in all sites of measurement. It was independent of age, body mass index and postmenopause duration. Associations were also found between adiponectin and BMD of LI-LIV and TH (β=-0.36 and -0.28, respectively), CCPA and BMD of FN and TH (β=-0.21, -0.24, respectively) and IL-6 and BMD of FN (β=0.37).Conclusion: The study of biochemical and immunological markers in women with RA demonstrated that CRP, CCPA, PTH, IL-6, adiponectin, and leptin influenced BMD.\",\"PeriodicalId\":0,\"journal\":{\"name\":\"\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0,\"publicationDate\":\"2024-06-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.26442/00403660.2024.05.202705\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.26442/00403660.2024.05.202705","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

摘要

目的：研究类风湿关节炎（RA）绝经后妇女的骨矿物质密度（BMD）与血清生化和免疫标记物之间的关系：研究对象包括 173 名患 RA 的妇女（年龄 61.0 [56.0; 66.0] 岁）。通过调查、双能 X 射线吸收测量法测量腰椎 (LI-LIV)、股骨颈 (FN) 和全髋 (TH) 的 BMD，常规血液化学，测量 C 反应蛋白 (CRP)、类风湿因子、环瓜氨酸肽抗体 (CCPA)、对甲状旁腺激素（PTH）、维生素 D3、肌生长因子、绒毛膜促性腺激素、白细胞介素-6（IL-6）、IL-6 受体、胰岛素样生长因子 1、脂肪连素、瘦素、成纤维细胞生长因子 23 和肿瘤坏死因子 SF12 进行了测定。结果显示在所有测量部位，PTH（β=-0.22，LI-LIV、FN 和 TH 分别为-0.35 和-0.30）、CRP（β=-0.18，LI-LIV、FN 和 TH 分别为 0.23 和-0.22）和瘦素（β=0.35，LI-LIV、FN 和 TH 分别为 0.32 和 0.42）均与 BMD 有显著关联。这与年龄、体重指数和绝经后持续时间无关。此外，还发现脂肪连素与 LI-LIV 和 TH 的 BMD（β=-0.36 和-0.28）、CCPA 与 FN 和 TH 的 BMD（β=-0.21 和-0.24）以及 IL-6 与 FN 的 BMD（β=0.37）之间存在关联：结论：对女性 RA 患者生化和免疫标记物的研究表明，CRP、CCPA、PTH、IL-6、脂肪连素和瘦素对 BMD 有影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文

[Bone mineral density in women with rheumatoid arthritis: A link between immune and biochemical markers].

Aim: To study the association of bone mineral density (BMD) with serum biochemical and immunological markers in postmenopausal women with rheumatoid arthritis (RA).

Materials and methods: The study included 173 women with RA (age 61.0 [56.0; 66.0] years). A survey, dual-energy X-ray absorptiometry to measure the BMD of the lumbar spine (L_I-L_IV), femoral neck (FN) and total hip (TH), routine blood chemistry, measurement of C-reactive protein (CRP), rheumatoid factor, cyclic citrullinated peptide antibodies (CCPA), parathyroid hormone (PTH), vitamin D₃, myostatin, follistatin, interleukin-6 (IL-6), IL-6 receptors, insulin-like growth factor 1, adiponectin, leptin, fibroblast growth factor 23, and tumor necrosis factor SF12 were performed.

Results: PTH (β=-0.22, -0.35 and -0.30 for L_I-L_IV, FN and TH, respectively), CRP (β=-0.18, 0.23 and -0.22 for L_I-L_IV, FN and TH, respectively) and leptin (β=0.35, 0.32 and 0.42 for L_I-L_IV, FN and TH, respectively) were shown a significant association with BMD in all sites of measurement. It was independent of age, body mass index and postmenopause duration. Associations were also found between adiponectin and BMD of L_I-L_IV and TH (β=-0.36 and -0.28, respectively), CCPA and BMD of FN and TH (β=-0.21, -0.24, respectively) and IL-6 and BMD of FN (β=0.37).

Conclusion: The study of biochemical and immunological markers in women with RA demonstrated that CRP, CCPA, PTH, IL-6, adiponectin, and leptin influenced BMD.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助