乳糜泻与慢性肾病之间的遗传关联:双样本孟德尔随机研究。

IF 3 3区 医学 Q1 UROLOGY & NEPHROLOGY
Renal Failure Pub Date : 2024-12-01 Epub Date: 2024-06-04 DOI:10.1080/0886022X.2024.2357246
Zhimin Chen, Zigui Zheng, Bingjing Jiang, Yanfang Xu
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引用次数: 0

摘要

摘要通过双样本孟德尔随机化(MR)分析,阐明乳糜泻对慢性肾脏病(CKD)风险的因果影响:该研究包括三项涉及欧洲血统个体的全基因组关联研究数据。研究组包括患有乳糜泻(n = 24,269 人)、慢性肾脏病(n = 117,165 人)和基于血清肌酐的肾小球滤过率估计水平(eGFRcrea,n = 133,413 人)的参与者。我们采用了四种广受认可的因果推断算法:MR-Egger、逆方差加权(IVW)、加权中位数和加权模式。为了解决与多效应和总体效应相关的潜在问题,我们进行了 MR-Egger 回归和 MR-PRESSO 全局检验。异质性采用 Cochran's Q 检验进行评估:我们确定了 14 个具有全基因组意义的遗传变异。MR分析在各种方法中提供了一致的证据,支持乳糜泻与CKD风险升高之间的因果关系(比值比(OR)IVW=1.027,P=0.025;OR加权中位数=1.028,P=0.049;OR加权模式=1.030,P=0.044)。此外,我们还观察到乳糜泻与 eGFRcrea 下降之间存在因果关系(ORIVW = 0.997,P = 2.94E-06;OR 加权中位数 = 0.996,P = 1.68E-05;OR 加权模式 = 0.996,P = 3.11E-04;ORMR Egger = 0.996,P = 5.00E-03)。根据 MR-Egger 回归、MR-PRESSO 和 Cochran's Q 检验,我们没有发现横向多效性、异质性或偏倚的重要证据:本研究结果表明,乳糜泻与慢性肾脏病风险增加之间存在因果关系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Genetic association between celiac disease and chronic kidney disease: a two-sample Mendelian randomization study.

Objective: A two-sample Mendelian randomization (MR) analysis was performed to elucidate the causal impact of celiac disease on the risk of chronic kidney disease (CKD).

Methods: The study comprised data from three genome-wide association studies involving individuals of European ancestry. The study groups included participants with celiac disease (n = 24,269), CKD (n = 117,165), and estimated glomerular filtration rate levels based on serum creatinine (eGFRcrea, n = 133,413). We employed four widely recognized causal inference algorithms: MR-Egger, inverse variance weighted (IVW), weighted median, and weighted mode. To address potential issues related to pleiotropy and overall effects, MR-Egger regression and the MR-PRESSO global test were performed. Heterogeneity was assessed using Cochran's Q test.

Results: We identified 14 genetic variants with genome-wide significance. The MR analysis provided consistent evidence across the various methodologies, supporting a causal relationship between celiac disease and an elevated risk of CKD (odds ratio (OR)IVW = 1.027, p = 0.025; ORweighted median = 1.028, P = 0.049; ORweighted mode = 1.030, p = 0.044). Furthermore, we observed a causal link between celiac disease and a decreased eGFRcrea (ORIVW = 0.997, P = 2.94E-06; ORweighted median = 0.996, P = 1.68E-05; ORweighted mode = 0.996, P = 3.11E-04; ORMR Egger = 0.996, P = 5.00E-03). We found no significant evidence of horizontal pleiotropy, heterogeneity, or bias based on MR-Egger regression, MR-PRESSO, and Cochran's Q test.

Conclusion: The results of this study indicate a causal relationship between celiac disease and an increased risk of CKD.

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来源期刊
Renal Failure
Renal Failure 医学-泌尿学与肾脏学
CiteScore
3.90
自引率
13.30%
发文量
374
审稿时长
1 months
期刊介绍: Renal Failure primarily concentrates on acute renal injury and its consequence, but also addresses advances in the fields of chronic renal failure, hypertension, and renal transplantation. Bringing together both clinical and experimental aspects of renal failure, this publication presents timely, practical information on pathology and pathophysiology of acute renal failure; nephrotoxicity of drugs and other substances; prevention, treatment, and therapy of renal failure; renal failure in association with transplantation, hypertension, and diabetes mellitus.
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