{"title":"乳糜泻与慢性肾病之间的遗传关联:双样本孟德尔随机研究。","authors":"Zhimin Chen, Zigui Zheng, Bingjing Jiang, Yanfang Xu","doi":"10.1080/0886022X.2024.2357246","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>A two-sample Mendelian randomization (MR) analysis was performed to elucidate the causal impact of celiac disease on the risk of chronic kidney disease (CKD).</p><p><strong>Methods: </strong>The study comprised data from three genome-wide association studies involving individuals of European ancestry. The study groups included participants with celiac disease (<i>n</i> = 24,269), CKD (<i>n</i> = 117,165), and estimated glomerular filtration rate levels based on serum creatinine (eGFRcrea, <i>n</i> = 133,413). We employed four widely recognized causal inference algorithms: MR-Egger, inverse variance weighted (IVW), weighted median, and weighted mode. To address potential issues related to pleiotropy and overall effects, MR-Egger regression and the MR-PRESSO global test were performed. Heterogeneity was assessed using Cochran's Q test.</p><p><strong>Results: </strong>We identified 14 genetic variants with genome-wide significance. The MR analysis provided consistent evidence across the various methodologies, supporting a causal relationship between celiac disease and an elevated risk of CKD (odds ratio (OR)<sub>IVW</sub> = 1.027, <i>p</i> = 0.025; OR<sub>weighted median</sub> = 1.028, <i>P</i> = 0.049; OR<sub>weighted mode</sub> = 1.030, <i>p</i> = 0.044). Furthermore, we observed a causal link between celiac disease and a decreased eGFRcrea (OR<sub>IVW</sub> = 0.997, <i>P</i> = 2.94E-06; OR<sub>weighted median</sub> = 0.996, <i>P</i> = 1.68E-05; OR<sub>weighted mode</sub> = 0.996, <i>P</i> = 3.11E-04; OR<sub>MR Egger</sub> = 0.996, <i>P</i> = 5.00E-03). We found no significant evidence of horizontal pleiotropy, heterogeneity, or bias based on MR-Egger regression, MR-PRESSO, and Cochran's Q test.</p><p><strong>Conclusion: </strong>The results of this study indicate a causal relationship between celiac disease and an increased risk of CKD.</p>","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":null,"pages":null},"PeriodicalIF":3.0000,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11151793/pdf/","citationCount":"0","resultStr":"{\"title\":\"Genetic association between celiac disease and chronic kidney disease: a two-sample Mendelian randomization study.\",\"authors\":\"Zhimin Chen, Zigui Zheng, Bingjing Jiang, Yanfang Xu\",\"doi\":\"10.1080/0886022X.2024.2357246\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>A two-sample Mendelian randomization (MR) analysis was performed to elucidate the causal impact of celiac disease on the risk of chronic kidney disease (CKD).</p><p><strong>Methods: </strong>The study comprised data from three genome-wide association studies involving individuals of European ancestry. The study groups included participants with celiac disease (<i>n</i> = 24,269), CKD (<i>n</i> = 117,165), and estimated glomerular filtration rate levels based on serum creatinine (eGFRcrea, <i>n</i> = 133,413). We employed four widely recognized causal inference algorithms: MR-Egger, inverse variance weighted (IVW), weighted median, and weighted mode. To address potential issues related to pleiotropy and overall effects, MR-Egger regression and the MR-PRESSO global test were performed. Heterogeneity was assessed using Cochran's Q test.</p><p><strong>Results: </strong>We identified 14 genetic variants with genome-wide significance. The MR analysis provided consistent evidence across the various methodologies, supporting a causal relationship between celiac disease and an elevated risk of CKD (odds ratio (OR)<sub>IVW</sub> = 1.027, <i>p</i> = 0.025; OR<sub>weighted median</sub> = 1.028, <i>P</i> = 0.049; OR<sub>weighted mode</sub> = 1.030, <i>p</i> = 0.044). Furthermore, we observed a causal link between celiac disease and a decreased eGFRcrea (OR<sub>IVW</sub> = 0.997, <i>P</i> = 2.94E-06; OR<sub>weighted median</sub> = 0.996, <i>P</i> = 1.68E-05; OR<sub>weighted mode</sub> = 0.996, <i>P</i> = 3.11E-04; OR<sub>MR Egger</sub> = 0.996, <i>P</i> = 5.00E-03). We found no significant evidence of horizontal pleiotropy, heterogeneity, or bias based on MR-Egger regression, MR-PRESSO, and Cochran's Q test.</p><p><strong>Conclusion: </strong>The results of this study indicate a causal relationship between celiac disease and an increased risk of CKD.</p>\",\"PeriodicalId\":20839,\"journal\":{\"name\":\"Renal Failure\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.0000,\"publicationDate\":\"2024-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11151793/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Renal Failure\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/0886022X.2024.2357246\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/6/4 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"UROLOGY & NEPHROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Renal Failure","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/0886022X.2024.2357246","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/6/4 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"UROLOGY & NEPHROLOGY","Score":null,"Total":0}
Genetic association between celiac disease and chronic kidney disease: a two-sample Mendelian randomization study.
Objective: A two-sample Mendelian randomization (MR) analysis was performed to elucidate the causal impact of celiac disease on the risk of chronic kidney disease (CKD).
Methods: The study comprised data from three genome-wide association studies involving individuals of European ancestry. The study groups included participants with celiac disease (n = 24,269), CKD (n = 117,165), and estimated glomerular filtration rate levels based on serum creatinine (eGFRcrea, n = 133,413). We employed four widely recognized causal inference algorithms: MR-Egger, inverse variance weighted (IVW), weighted median, and weighted mode. To address potential issues related to pleiotropy and overall effects, MR-Egger regression and the MR-PRESSO global test were performed. Heterogeneity was assessed using Cochran's Q test.
Results: We identified 14 genetic variants with genome-wide significance. The MR analysis provided consistent evidence across the various methodologies, supporting a causal relationship between celiac disease and an elevated risk of CKD (odds ratio (OR)IVW = 1.027, p = 0.025; ORweighted median = 1.028, P = 0.049; ORweighted mode = 1.030, p = 0.044). Furthermore, we observed a causal link between celiac disease and a decreased eGFRcrea (ORIVW = 0.997, P = 2.94E-06; ORweighted median = 0.996, P = 1.68E-05; ORweighted mode = 0.996, P = 3.11E-04; ORMR Egger = 0.996, P = 5.00E-03). We found no significant evidence of horizontal pleiotropy, heterogeneity, or bias based on MR-Egger regression, MR-PRESSO, and Cochran's Q test.
Conclusion: The results of this study indicate a causal relationship between celiac disease and an increased risk of CKD.
期刊介绍:
Renal Failure primarily concentrates on acute renal injury and its consequence, but also addresses advances in the fields of chronic renal failure, hypertension, and renal transplantation. Bringing together both clinical and experimental aspects of renal failure, this publication presents timely, practical information on pathology and pathophysiology of acute renal failure; nephrotoxicity of drugs and other substances; prevention, treatment, and therapy of renal failure; renal failure in association with transplantation, hypertension, and diabetes mellitus.