Sarah Algodayan, Ramya Balachandar, Nikolaos Papathanasiou, Jamshed Bomanji, John B Porter, Julian Waung
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引用次数: 0
摘要
研究目的本研究旨在通过序列分析评估地中海贫血症对骨矿物质密度(BMD)的长期影响,比较男性和女性患者 BMD 值的变化,并寻找成年地中海贫血症患者 BMD 与生化指标之间的相关性。BMD 是一种骨矿密度检测方法,使用双能 X 射线测量单位骨骼中的羟基磷灰石钙,反映骨骼强度:我们进行了一项纵向回顾性队列研究,以确定成年地中海贫血症患者 BMD 值和生化指标的变化。使用 Hologic 的骨双能 X 射线吸收仪对腰椎(L1-L4)和股骨近端进行 BMD 评估。从电子记录中检索了五个连续的 BMD 值。同时还评估了生化参数,包括血清钙、磷和 25- 羟维生素 D 水平:结果:共纳入 108 名患者(47 名男性,61 名女性;中位年龄:44 岁),其中重型地中海贫血 71 名,中型地中海贫血 20 名,血红蛋白 E 型地中海贫血 14 名,α 型地中海贫血 3 名。在三十年的分析中,地中海贫血症患者的低 BMD 发生率从 64% 上升到 74%。女性和重型地中海贫血患者的髋部 BMD 值和相应的 Z 值均较低:结论:成年地中海贫血症患者的 BMD 值会逐渐下降,这在女性重型地中海贫血症患者中尤为明显。然而,在长期评估中未观察到生化参数发生变化。
Bone mineral density in adult thalassaemias: a retrospective longitudinal study.
Objectives: In this study, we aim to evaluate the long-term impact of thalassaemia on bone mineral density (BMD) through sequential analysis, compare changes in BMD values between male and female patients and find any correlation between BMD and biochemical markers in the adult thalassaemia group. BMD is a bone mineral density test using dual-energy X-ray to measure calcium hydroxyapatite per unit of bone, reflecting bone strength.
Methods: We conducted a longitudinal retrospective observational cohort study to determine the changes in BMD values and biochemical parameters in adult thalassaemia patients. BMD was assessed at the lumbar spine (L1-L4) and proximal femora using Hologic's bone dual-energy X-ray absorptiometry. Five serial BMD values were retrieved from electronic records. Biochemical parameters, including serum calcium, phosphorus and 25-hydroxyvitamin D levels, were also assessed.
Results: A total of 108 patients (47 males and 61 females; median age: 44 years) with thalassaemia major 71 patients, intermedia 20 patients, haemoglobin E disease 14 patients and thalassaemia-alpha three patients were included. The incidence of low BMD in patients with thalassaemia increased from 64 to 74% over three decades of analysis. Females and thalassaemia major patients had lower hip BMD values and corresponding Z -scores.
Conclusion: There is a progressive decline in BMD values in adult thalassaemia, which was apparent in female thalassaemia major patients. No changes in biochemical parameters, however, were observed over long-term assessments.
期刊介绍:
Nuclear Medicine Communications, the official journal of the British Nuclear Medicine Society, is a rapid communications journal covering nuclear medicine and molecular imaging with radionuclides, and the basic supporting sciences. As well as clinical research and commentary, manuscripts describing research on preclinical and basic sciences (radiochemistry, radiopharmacy, radiobiology, radiopharmacology, medical physics, computing and engineering, and technical and nursing professions involved in delivering nuclear medicine services) are welcomed, as the journal is intended to be of interest internationally to all members of the many medical and non-medical disciplines involved in nuclear medicine. In addition to papers reporting original studies, frankly written editorials and topical reviews are a regular feature of the journal.