Martin de la Presa, Brandon McCafferty, Michael A. Page
{"title":"贝维氏菌引起的难治性角膜炎--使用两性霉素 B 和米卡芬净进行腔内治疗获得成功","authors":"Martin de la Presa, Brandon McCafferty, Michael A. Page","doi":"10.1097/j.jcro.0000000000000017","DOIUrl":null,"url":null,"abstract":"A case of Beauveria bassiana keratitis refractory to treatment with topical and systemic antifungal agents that demonstrated high-sensitivity profiles was presented. Clinical resolution was achieved within 1 month after the implementation of intrastromal injections of amphotericin B and micafungin. Keratitis from B. bassiana is a rare fungal species without a well-defined management strategy. To our knowledge, no previous reports have described the effectiveness or therapeutic use of intrastromal micafungin. This case report highlights a previously unreported treatment for cases of refractory keratitis from this rare fungal infection.","PeriodicalId":227563,"journal":{"name":"Journal of Cataract and Refractive Surgery Online Case Reports","volume":" 9","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2020-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"Refractory keratitis from Beauveria bassiana—Successful treatment with intrastromal amphotericin B and micafungin\",\"authors\":\"Martin de la Presa, Brandon McCafferty, Michael A. Page\",\"doi\":\"10.1097/j.jcro.0000000000000017\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"A case of Beauveria bassiana keratitis refractory to treatment with topical and systemic antifungal agents that demonstrated high-sensitivity profiles was presented. Clinical resolution was achieved within 1 month after the implementation of intrastromal injections of amphotericin B and micafungin. Keratitis from B. bassiana is a rare fungal species without a well-defined management strategy. To our knowledge, no previous reports have described the effectiveness or therapeutic use of intrastromal micafungin. This case report highlights a previously unreported treatment for cases of refractory keratitis from this rare fungal infection.\",\"PeriodicalId\":227563,\"journal\":{\"name\":\"Journal of Cataract and Refractive Surgery Online Case Reports\",\"volume\":\" 9\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-03-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Cataract and Refractive Surgery Online Case Reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1097/j.jcro.0000000000000017\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Cataract and Refractive Surgery Online Case Reports","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1097/j.jcro.0000000000000017","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 2
摘要
本报告介绍了一例经局部和全身抗真菌药物治疗无效的巴氏杆菌角膜炎病例。该病例在接受两性霉素 B 和米卡芬净的腔内注射后 1 个月内临床症状得到缓解。巴氏角膜炎是一种罕见的真菌,没有明确的治疗策略。据我们所知,以前没有任何报道描述过基质内注射米卡芬净的有效性或治疗用途。本病例报告重点介绍了一种以前从未报道过的治疗这种罕见真菌感染引起的难治性角膜炎的方法。
Refractory keratitis from Beauveria bassiana—Successful treatment with intrastromal amphotericin B and micafungin
A case of Beauveria bassiana keratitis refractory to treatment with topical and systemic antifungal agents that demonstrated high-sensitivity profiles was presented. Clinical resolution was achieved within 1 month after the implementation of intrastromal injections of amphotericin B and micafungin. Keratitis from B. bassiana is a rare fungal species without a well-defined management strategy. To our knowledge, no previous reports have described the effectiveness or therapeutic use of intrastromal micafungin. This case report highlights a previously unreported treatment for cases of refractory keratitis from this rare fungal infection.