基于底物的 1,3,4-恶二唑合成策略和生物活性:综述。

IF 3.2 4区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Upasana Sharma, Rajnish Kumar, Avijit Mazumder,  Salahuddin, Neelima Kukreti, Rashmi Mishra, M. V. N. L. Chaitanya
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引用次数: 0

摘要

五元 1,3,4-恶二唑杂环因其独特的生物异构特性和异常广泛的生物活性而备受关注。自 1,3,4-恶二唑被发现一个世纪以来,其不寻常的潜力吸引了药物化学家的注意,导致发现了一些目前可获得的含有 1,3,4-恶二唑单元的药物,并授予了大量与 1,3,4-恶二唑相关的研究专利。值得注意的是,在过去几年中,人们对 1,3,4-恶二唑的生物应用兴趣倍增。在此,本综述全面概述了 1,3,4-噁二唑基化合物合成方面的最新成果,重点介绍了过去 10 年中其生物应用方面的主要进展,并简要评述了进一步发展的前景。我们希望各科学流派的研究人员在设计与 1,3,4-恶二唑相关的工作时能从这些综述文章中获益。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Substrate-based synthetic strategies and biological activities of 1,3,4-oxadiazole: A review

Substrate-based synthetic strategies and biological activities of 1,3,4-oxadiazole: A review

Substrate-based synthetic strategies and biological activities of 1,3,4-oxadiazole: A review

The five-membered 1,3,4-oxadiazole heterocyclic ring has received considerable attention because of its unique bio-isosteric properties and an unusually wide spectrum of biological activities. After a century since 1,3,4-oxadiazole was discovered, its uncommon potential attracted medicinal chemist's attention, leading to the discovery of a few presently accessible drugs containing 1,3,4-oxadiazole units, and a large number of patents have been granted on research related to 1,3,4-oxadiazole. It is worth noting that interest in 1,3,4-oxadiazoles' biological applications has doubled in the last few years. Herein, this review presents a comprehensive overview of the recent achievements in the synthesis of 1,3,4-oxadiazole-based compounds and highlights the major advances in their biological applications in the last 10 years, as well as brief remarks on prospects for further development. We hope that researchers across the scientific streams will benefit from the presented review articles for designing their work related to 1,3,4-oxadiazoles.

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来源期刊
Chemical Biology & Drug Design
Chemical Biology & Drug Design 医学-生化与分子生物学
CiteScore
5.10
自引率
3.30%
发文量
164
审稿时长
4.4 months
期刊介绍: Chemical Biology & Drug Design is a peer-reviewed scientific journal that is dedicated to the advancement of innovative science, technology and medicine with a focus on the multidisciplinary fields of chemical biology and drug design. It is the aim of Chemical Biology & Drug Design to capture significant research and drug discovery that highlights new concepts, insight and new findings within the scope of chemical biology and drug design.
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