细胞应激和癌症中的非规范 mRNA 翻译启动

IF 3.4 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
NAR cancer Pub Date : 2024-05-31 eCollection Date: 2024-06-01 DOI:10.1093/narcan/zcae026
Mélanie Mahé, Tiffany Rios-Fuller, Olga Katsara, Robert J Schneider
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引用次数: 0

摘要

由帽子结合蛋白 eIF4E 识别 m7G "帽子 "并组装由支架蛋白 eIF4G 和 RNA 螺旋酶 eIF4A 组成的典型预启动复合物的典型 mRNA 翻译启动机制现已得到很好的描述,这一机制历来被认为可以描述所有细胞的 mRNA 翻译。然而,在过去的十年中,人们发现了典型 eIF4E 介导的 mRNA 翻译启动的替代机制。研究表明,在细胞生理和病理应激条件下,细胞 mRNA 翻译启动的非规范替代机制,无论是依赖于帽子还是独立于帽子,都能提供 mRNA 的选择性翻译。这些条件通常涉及典型的 eIF4E1/cap 介导的 mRNA 翻译的全面下调,以及细胞蛋白质组的选择性翻译重编程,如在肿瘤发生和恶性进展过程中发生的情况。癌细胞必须能够保持生理可塑性,以获得迁移表型、侵入组织、转移、存活并适应严重的微环境应激条件,这涉及到对典型 mRNA 翻译起始的抑制。在这篇综述中,我们描述了非规范的、交替的 mRNA 翻译起始机制在癌症中新出现的重要作用,特别是在适应应激以及恶性进展和转移所涉及的表型细胞命运变化方面。这些交替翻译启动机制为肿瘤治疗药物的开发提供了新的靶点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Non-canonical mRNA translation initiation in cell stress and cancer.

The now well described canonical mRNA translation initiation mechanism of m7G 'cap' recognition by cap-binding protein eIF4E and assembly of the canonical pre-initiation complex consisting of scaffolding protein eIF4G and RNA helicase eIF4A has historically been thought to describe all cellular mRNA translation. However, the past decade has seen the discovery of alternative mechanisms to canonical eIF4E mediated mRNA translation initiation. Studies have shown that non-canonical alternate mechanisms of cellular mRNA translation initiation, whether cap-dependent or independent, serve to provide selective translation of mRNAs under cell physiological and pathological stress conditions. These conditions typically involve the global downregulation of canonical eIF4E1/cap-mediated mRNA translation, and selective translational reprogramming of the cell proteome, as occurs in tumor development and malignant progression. Cancer cells must be able to maintain physiological plasticity to acquire a migratory phenotype, invade tissues, metastasize, survive and adapt to severe microenvironmental stress conditions that involve inhibition of canonical mRNA translation initiation. In this review we describe the emerging, important role of non-canonical, alternate mechanisms of mRNA translation initiation in cancer, particularly in adaptation to stresses and the phenotypic cell fate changes involved in malignant progression and metastasis. These alternate translation initiation mechanisms provide new targets for oncology therapeutics development.

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CiteScore
6.90
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13 weeks
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