Sümeyye Koç, Sedat Şen, Yüksel Terzi, Ferah Kızılay, Serkan Demir, Dürdane Bekar Aksoy, Fatma Kurtuluş, Nuray Bilge, Egemen Idilman, Cihat Uzunköprü, Serdal Güngör, Vedat Çilingir, Özlem Ethemoğlu, Cavit Boz, Haluk Gümüş, Ahmet Kasım Kılıç, Ayşin Kısabay, Levent Sinan Bir, Ömer Faruk Turan, Aysun Soysal, Mesrure Köseoğlu, Gülnur Tekgöl Uzuner, Hasan Bayındır, Sibel Canbaz Kabay, Mustafa Çam, Vildan Yayla, Hüseyin Tan, Abdülcemal Özcan, Özlem Taşkapıoğlu, Muammer Korkmaz, Yusuf Tamam, Yılmaz İnanç, Hüsnü Efendi, Dilcan Kotan, Mehmet Fatih Yetkin, Adnan Burak Bilgiç, Hikmet Saçmacı, Serpil Demirci, Yahya Çelik, Turan Poyraz, Murat Terzi
{"title":"显示髓鞘少突胶质细胞蛋白抗体的患者的临床、人口统计学和放射学特征","authors":"Sümeyye Koç, Sedat Şen, Yüksel Terzi, Ferah Kızılay, Serkan Demir, Dürdane Bekar Aksoy, Fatma Kurtuluş, Nuray Bilge, Egemen Idilman, Cihat Uzunköprü, Serdal Güngör, Vedat Çilingir, Özlem Ethemoğlu, Cavit Boz, Haluk Gümüş, Ahmet Kasım Kılıç, Ayşin Kısabay, Levent Sinan Bir, Ömer Faruk Turan, Aysun Soysal, Mesrure Köseoğlu, Gülnur Tekgöl Uzuner, Hasan Bayındır, Sibel Canbaz Kabay, Mustafa Çam, Vildan Yayla, Hüseyin Tan, Abdülcemal Özcan, Özlem Taşkapıoğlu, Muammer Korkmaz, Yusuf Tamam, Yılmaz İnanç, Hüsnü Efendi, Dilcan Kotan, Mehmet Fatih Yetkin, Adnan Burak Bilgiç, Hikmet Saçmacı, Serpil Demirci, Yahya Çelik, Turan Poyraz, Murat Terzi","doi":"10.4274/balkanmedj.galenos.2024.2024-1-97","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Optic neuritis, myelitis, and neuromyelitis optica spectrum disorder (NMOSD) have been associated with antibodies against myelin oligodendrocyte glycoprotein-immunoglobulin G (anti-MOG-IgG). Furthermore, patients with radiological and demographic features atypical for multiple sclerosis (MS) with optic neuritis and myelitis also demonstrate antibodies against aquaporin-4 and anti-MOG-IgG. However, data on the diagnosis, treatment, follow-up, and prognosis in patients with anti-MOG-IgG are limited.</p><p><strong>Aims: </strong>To evaluate the clinical, radiological, and demographic characteristics of patients with anti-MOG-IgG.</p><p><strong>Study design: </strong>Multicenter, retrospective, observational study.</p><p><strong>Methods: </strong>Patients with blood samples demonstrating anti-MOG-IgG that had been evaluated at the Neuroimmunology laboratory at Ondokuz Mayıs University’s Faculty of Medicine were included in the study.</p><p><strong>Results: </strong>Of the 104 patients with anti-MOG-IgG, 56.7% were women and 43.3% were men. Approximately 2.4% of the patients were diagnosed with MS, 15.8% with acute disseminated encephalomyelitis (ADEM), 39.4% with NMOSD, 31.3% with isolated optic neuritis, and 11.1% with isolated myelitis. Approximately 53.1% of patients with spinal involvement at clinical onset demonstrated a clinical course of NMOSD. Thereafter, 8.8% of these patients demonstrated a clinical course similar to MS and ADEM, and 28.1% demonstrated a clinical course of isolated myelitis. The response to acute attack treatment was lower and the disability was higher in patients aged > 40 years than patients aged < 40 years at clinical onset. Oligoclonal band was detected in 15.5% of the patients.</p><p><strong>Conclusion: </strong>For patients with NMOSD and without anti-NMO antibodies, the diagnosis is supported by the presence of anti-MOG-IgG. Furthermore, advanced age at clinical onset, Expanded Disability Status Scale (EDSS) score at clinical onset, spinal cord involvement, and number of attacks may be negative prognostic factors in patients with anti-MOG-IgG.</p>","PeriodicalId":8690,"journal":{"name":"Balkan Medical Journal","volume":" ","pages":"272-279"},"PeriodicalIF":1.9000,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11588904/pdf/","citationCount":"0","resultStr":"{\"title\":\"Clinical, Demographic, and Radiological Characteristics of Patients Demonstrating Antibodies Against Myelin Oligodendrocyte Glycoprotein\",\"authors\":\"Sümeyye Koç, Sedat Şen, Yüksel Terzi, Ferah Kızılay, Serkan Demir, Dürdane Bekar Aksoy, Fatma Kurtuluş, Nuray Bilge, Egemen Idilman, Cihat Uzunköprü, Serdal Güngör, Vedat Çilingir, Özlem Ethemoğlu, Cavit Boz, Haluk Gümüş, Ahmet Kasım Kılıç, Ayşin Kısabay, Levent Sinan Bir, Ömer Faruk Turan, Aysun Soysal, Mesrure Köseoğlu, Gülnur Tekgöl Uzuner, Hasan Bayındır, Sibel Canbaz Kabay, Mustafa Çam, Vildan Yayla, Hüseyin Tan, Abdülcemal Özcan, Özlem Taşkapıoğlu, Muammer Korkmaz, Yusuf Tamam, Yılmaz İnanç, Hüsnü Efendi, Dilcan Kotan, Mehmet Fatih Yetkin, Adnan Burak Bilgiç, Hikmet Saçmacı, Serpil Demirci, Yahya Çelik, Turan Poyraz, Murat Terzi\",\"doi\":\"10.4274/balkanmedj.galenos.2024.2024-1-97\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Optic neuritis, myelitis, and neuromyelitis optica spectrum disorder (NMOSD) have been associated with antibodies against myelin oligodendrocyte glycoprotein-immunoglobulin G (anti-MOG-IgG). Furthermore, patients with radiological and demographic features atypical for multiple sclerosis (MS) with optic neuritis and myelitis also demonstrate antibodies against aquaporin-4 and anti-MOG-IgG. However, data on the diagnosis, treatment, follow-up, and prognosis in patients with anti-MOG-IgG are limited.</p><p><strong>Aims: </strong>To evaluate the clinical, radiological, and demographic characteristics of patients with anti-MOG-IgG.</p><p><strong>Study design: </strong>Multicenter, retrospective, observational study.</p><p><strong>Methods: </strong>Patients with blood samples demonstrating anti-MOG-IgG that had been evaluated at the Neuroimmunology laboratory at Ondokuz Mayıs University’s Faculty of Medicine were included in the study.</p><p><strong>Results: </strong>Of the 104 patients with anti-MOG-IgG, 56.7% were women and 43.3% were men. Approximately 2.4% of the patients were diagnosed with MS, 15.8% with acute disseminated encephalomyelitis (ADEM), 39.4% with NMOSD, 31.3% with isolated optic neuritis, and 11.1% with isolated myelitis. Approximately 53.1% of patients with spinal involvement at clinical onset demonstrated a clinical course of NMOSD. Thereafter, 8.8% of these patients demonstrated a clinical course similar to MS and ADEM, and 28.1% demonstrated a clinical course of isolated myelitis. The response to acute attack treatment was lower and the disability was higher in patients aged > 40 years than patients aged < 40 years at clinical onset. Oligoclonal band was detected in 15.5% of the patients.</p><p><strong>Conclusion: </strong>For patients with NMOSD and without anti-NMO antibodies, the diagnosis is supported by the presence of anti-MOG-IgG. Furthermore, advanced age at clinical onset, Expanded Disability Status Scale (EDSS) score at clinical onset, spinal cord involvement, and number of attacks may be negative prognostic factors in patients with anti-MOG-IgG.</p>\",\"PeriodicalId\":8690,\"journal\":{\"name\":\"Balkan Medical Journal\",\"volume\":\" \",\"pages\":\"272-279\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2024-07-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11588904/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Balkan Medical Journal\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.4274/balkanmedj.galenos.2024.2024-1-97\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/6/3 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Balkan Medical Journal","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.4274/balkanmedj.galenos.2024.2024-1-97","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/6/3 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
Clinical, Demographic, and Radiological Characteristics of Patients Demonstrating Antibodies Against Myelin Oligodendrocyte Glycoprotein
Background: Optic neuritis, myelitis, and neuromyelitis optica spectrum disorder (NMOSD) have been associated with antibodies against myelin oligodendrocyte glycoprotein-immunoglobulin G (anti-MOG-IgG). Furthermore, patients with radiological and demographic features atypical for multiple sclerosis (MS) with optic neuritis and myelitis also demonstrate antibodies against aquaporin-4 and anti-MOG-IgG. However, data on the diagnosis, treatment, follow-up, and prognosis in patients with anti-MOG-IgG are limited.
Aims: To evaluate the clinical, radiological, and demographic characteristics of patients with anti-MOG-IgG.
Study design: Multicenter, retrospective, observational study.
Methods: Patients with blood samples demonstrating anti-MOG-IgG that had been evaluated at the Neuroimmunology laboratory at Ondokuz Mayıs University’s Faculty of Medicine were included in the study.
Results: Of the 104 patients with anti-MOG-IgG, 56.7% were women and 43.3% were men. Approximately 2.4% of the patients were diagnosed with MS, 15.8% with acute disseminated encephalomyelitis (ADEM), 39.4% with NMOSD, 31.3% with isolated optic neuritis, and 11.1% with isolated myelitis. Approximately 53.1% of patients with spinal involvement at clinical onset demonstrated a clinical course of NMOSD. Thereafter, 8.8% of these patients demonstrated a clinical course similar to MS and ADEM, and 28.1% demonstrated a clinical course of isolated myelitis. The response to acute attack treatment was lower and the disability was higher in patients aged > 40 years than patients aged < 40 years at clinical onset. Oligoclonal band was detected in 15.5% of the patients.
Conclusion: For patients with NMOSD and without anti-NMO antibodies, the diagnosis is supported by the presence of anti-MOG-IgG. Furthermore, advanced age at clinical onset, Expanded Disability Status Scale (EDSS) score at clinical onset, spinal cord involvement, and number of attacks may be negative prognostic factors in patients with anti-MOG-IgG.
期刊介绍：
The Balkan Medical Journal (Balkan Med J) is a peer-reviewed open-access international journal that publishes interesting clinical and experimental research conducted in all fields of medicine, interesting case reports and clinical images, invited reviews, editorials, letters, comments and letters to the Editor including reports on publication and research ethics. The journal is the official scientific publication of the Trakya University Faculty of Medicine, Edirne, Turkey and is printed six times a year, in January, March, May, July, September and November. The language of the journal is English.
The journal is based on independent and unbiased double-blinded peer-reviewed principles. Only unpublished papers that are not under review for publication elsewhere can be submitted. Balkan Medical Journal does not accept multiple submission and duplicate submission even though the previous one was published in a different language. The authors are responsible for the scientific content of the material to be published. The Balkan Medical Journal reserves the right to request any research materials on which the paper is based.
The Balkan Medical Journal encourages and enables academicians, researchers, specialists and primary care physicians of Balkan countries to publish their valuable research in all branches of medicine. The primary aim of the journal is to publish original articles with high scientific and ethical quality and serve as a good example of medical publications in the Balkans as well as in the World.
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