罕见癌症的 Optimus-Era 剂量发现

IF 29.7 1区医学 Q1 ONCOLOGY

Cancer discovery Pub Date : 2024-06-03 DOI:10.1158/2159-8290.CD-24-0368

Yonina R Murciano-Goroff, Sean M Devlin, Alexia Iasonos, Alexander Drilon

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引用次数: 0

摘要

摘要：癌症生物学和诊断学的进步使人们认识到了多种罕见癌症亚型，从而强调了迫切需要制定战略来加快针对这些癌症患者的药物开发。本文探讨了在累积少量罕见癌症患者的试验中寻找剂量的独特挑战；根据美国食品药品管理局 Optimus 项目时代不断发展的剂量确定方法，提出了剂量优化策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Optimus-Era Dose Finding for Rare Cancers.

Summary: Advances in cancer biology and diagnostics have led to the recognition of a multitude of rare cancer subtypes, emphasizing the pressing need for strategies to accelerate drug development for patients with these cancers. This paper addresses the unique challenges of dose finding in trials that accrue small numbers of patients with rare cancers; strategies for dose optimization are proposed, in line with evolving approaches to dose determination in the age of the US Food and Drug Administration's Project Optimus.

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来源期刊

Cancer discovery ONCOLOGY-

CiteScore

22.90

自引率

1.40%

发文量

838

审稿时长

6-12 weeks

期刊介绍： Cancer Discovery publishes high-impact, peer-reviewed articles detailing significant advances in both research and clinical trials. Serving as a premier cancer information resource, the journal also features Review Articles, Perspectives, Commentaries, News stories, and Research Watch summaries to keep readers abreast of the latest findings in the field. Covering a wide range of topics, from laboratory research to clinical trials and epidemiologic studies, Cancer Discovery spans the entire spectrum of cancer research and medicine.