以甲醇为 C1 源从α-四氢呋喃酮衍生物电化学合成螺内酯。

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2024-06-02 DOI:10.1021/acs.orglett.4c01678

Wei Xiao, Jianyan Wang, Jiamin Ye, Hongyan Wang, Jie Wu* and Shengqing Ye*,

{"title":"以甲醇为 C1 源从α-四氢呋喃酮衍生物电化学合成螺内酯。","authors":"Wei Xiao, Jianyan Wang, Jiamin Ye, Hongyan Wang, Jie Wu* and Shengqing Ye*, ","doi":"10.1021/acs.orglett.4c01678","DOIUrl":null,"url":null,"abstract":"<p >Spirolactones are widely found in pharmaceuticals and bioactive natural products. However, efficient and environmentally friendly approaches to accessing spirolactones are still highly desirable. Herein, a novel electrochemical synthesis of spirolactones from α-tetralone derivatives with methanol as a C1 source is described. This electrochemical reaction exhibits a high efficiency and good functional group tolerance.</p>","PeriodicalId":54,"journal":{"name":"Organic Letters","volume":"26 23","pages":"5016–5020"},"PeriodicalIF":5.0000,"publicationDate":"2024-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Electrochemical Synthesis of Spirolactones from α-Tetralone Derivatives with Methanol as a C1 Source\",\"authors\":\"Wei Xiao, Jianyan Wang, Jiamin Ye, Hongyan Wang, Jie Wu* and Shengqing Ye*, \",\"doi\":\"10.1021/acs.orglett.4c01678\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p >Spirolactones are widely found in pharmaceuticals and bioactive natural products. However, efficient and environmentally friendly approaches to accessing spirolactones are still highly desirable. Herein, a novel electrochemical synthesis of spirolactones from α-tetralone derivatives with methanol as a C1 source is described. This electrochemical reaction exhibits a high efficiency and good functional group tolerance.</p>\",\"PeriodicalId\":54,\"journal\":{\"name\":\"Organic Letters\",\"volume\":\"26 23\",\"pages\":\"5016–5020\"},\"PeriodicalIF\":5.0000,\"publicationDate\":\"2024-06-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Organic Letters\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://pubs.acs.org/doi/10.1021/acs.orglett.4c01678\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, ORGANIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Organic Letters","FirstCategoryId":"92","ListUrlMain":"https://pubs.acs.org/doi/10.1021/acs.orglett.4c01678","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}

引用次数: 0

摘要

螺内酯广泛存在于药品和具有生物活性的天然产品中。然而，高效、环保的方法仍然是获取螺内酯的最佳途径。本文介绍了一种以甲醇为 C1 源，从 α-tetralone 衍生物中电化学合成螺内酯的新方法。该电化学反应具有高效率和良好的官能团耐受性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Electrochemical Synthesis of Spirolactones from α-Tetralone Derivatives with Methanol as a C1 Source

查看原文本刊更多论文

Electrochemical Synthesis of Spirolactones from α-Tetralone Derivatives with Methanol as a C1 Source

Spirolactones are widely found in pharmaceuticals and bioactive natural products. However, efficient and environmentally friendly approaches to accessing spirolactones are still highly desirable. Herein, a novel electrochemical synthesis of spirolactones from α-tetralone derivatives with methanol as a C1 source is described. This electrochemical reaction exhibits a high efficiency and good functional group tolerance.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.