生物醇回收下游加工性能透视

IF 2.8 4区 生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Tamara Janković, Adrie JJ Straathof, Anton A Kiss
{"title":"生物醇回收下游加工性能透视","authors":"Tamara Janković,&nbsp;Adrie JJ Straathof,&nbsp;Anton A Kiss","doi":"10.1002/jctb.7690","DOIUrl":null,"url":null,"abstract":"<p>Even though industrial biotechnology is successfully used for the production of some chemicals, for many other chemicals it is not yet competitive with conventional petrochemical production. Usually, fermentation as well as downstream processing requires improvement. Downstream processing has to deal with low product concentrations, microorganisms, impurities and thermodynamic constraints (e.g., azeotropes), which often makes it very challenging and expensive, especially on a large scale. However, downstream processing of biochemicals has not attracted as much attention as upstream fermentation processes. In that context, this perspective paper offers a lightly referenced scholarly opinion about the downstream processing performance of different bioalcohols after fermentation. Due to the stronger toxicity effects on microbes, the achievable concentrations of monohydric aliphatic alcohols in the fermentation broth decrease with the increasing chain length. Specifically, the concentrations used here are 6.14, 5.00, 1.61 and 0.24 wt% of ethanol, isopropanol, isobutanol and hexanol, respectively. More dilute fermentation broths lead to more complex recovery processes. According to our previous work, the total purification costs increase from 0.080 USD kg<sup>−1</sup> for ethanol, 0.109 USD kg<sup>−1</sup> for isopropanol and 0.161 USD kg<sup>−1</sup> for isobutanol to 0.529 USD kg<sup>−1</sup> for hexanol. A similar trend is noticeable for the energy usage (0.960, 1.348, 2.018 and 3.069 kW<sub>th</sub>h kg<sup>−1</sup>, respectively) and the related CO<sub>2</sub> emissions (0.164, 0.221, 0.449 and 0.555 kg<sub>CO2</sub> kg<sup>−1</sup>, respectively). This work shows that advanced separation and purification based on process intensification principles are crucial for overall efficient production processes. The achievable product concentration in the fermentation broth – and not so much the alcohol chain length – has the biggest influence on the performance of downstream processing. Therefore, simultaneous development of both upstream and downstream processing is necessary to ensure the competitiveness and viability of industrial fermentation processes. © 2024 The Author(s). <i>Journal of Chemical Technology and Biotechnology</i> published by John Wiley &amp; Sons Ltd on behalf of Society of Chemical Industry (SCI).</p>","PeriodicalId":15335,"journal":{"name":"Journal of chemical technology and biotechnology","volume":null,"pages":null},"PeriodicalIF":2.8000,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jctb.7690","citationCount":"0","resultStr":"{\"title\":\"A perspective on downstream processing performance for recovery of bioalcohols\",\"authors\":\"Tamara Janković,&nbsp;Adrie JJ Straathof,&nbsp;Anton A Kiss\",\"doi\":\"10.1002/jctb.7690\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Even though industrial biotechnology is successfully used for the production of some chemicals, for many other chemicals it is not yet competitive with conventional petrochemical production. Usually, fermentation as well as downstream processing requires improvement. Downstream processing has to deal with low product concentrations, microorganisms, impurities and thermodynamic constraints (e.g., azeotropes), which often makes it very challenging and expensive, especially on a large scale. However, downstream processing of biochemicals has not attracted as much attention as upstream fermentation processes. In that context, this perspective paper offers a lightly referenced scholarly opinion about the downstream processing performance of different bioalcohols after fermentation. Due to the stronger toxicity effects on microbes, the achievable concentrations of monohydric aliphatic alcohols in the fermentation broth decrease with the increasing chain length. Specifically, the concentrations used here are 6.14, 5.00, 1.61 and 0.24 wt% of ethanol, isopropanol, isobutanol and hexanol, respectively. More dilute fermentation broths lead to more complex recovery processes. According to our previous work, the total purification costs increase from 0.080 USD kg<sup>−1</sup> for ethanol, 0.109 USD kg<sup>−1</sup> for isopropanol and 0.161 USD kg<sup>−1</sup> for isobutanol to 0.529 USD kg<sup>−1</sup> for hexanol. A similar trend is noticeable for the energy usage (0.960, 1.348, 2.018 and 3.069 kW<sub>th</sub>h kg<sup>−1</sup>, respectively) and the related CO<sub>2</sub> emissions (0.164, 0.221, 0.449 and 0.555 kg<sub>CO2</sub> kg<sup>−1</sup>, respectively). This work shows that advanced separation and purification based on process intensification principles are crucial for overall efficient production processes. The achievable product concentration in the fermentation broth – and not so much the alcohol chain length – has the biggest influence on the performance of downstream processing. Therefore, simultaneous development of both upstream and downstream processing is necessary to ensure the competitiveness and viability of industrial fermentation processes. © 2024 The Author(s). <i>Journal of Chemical Technology and Biotechnology</i> published by John Wiley &amp; Sons Ltd on behalf of Society of Chemical Industry (SCI).</p>\",\"PeriodicalId\":15335,\"journal\":{\"name\":\"Journal of chemical technology and biotechnology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.8000,\"publicationDate\":\"2024-05-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jctb.7690\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of chemical technology and biotechnology\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/jctb.7690\",\"RegionNum\":4,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"BIOTECHNOLOGY & APPLIED MICROBIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of chemical technology and biotechnology","FirstCategoryId":"5","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/jctb.7690","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

尽管工业生物技术已成功用于某些化学品的生产,但在许多其他化学品的生产方面,它还无法与传统的石油化工生产竞争。通常,发酵和下游加工都需要改进。下游加工必须处理产品浓度低、微生物、杂质和热力学限制(如共沸物)等问题,这往往使其变得非常具有挑战性和昂贵,尤其是在大规模生产中。然而,生化产品的下游加工并没有像上游发酵工艺那样受到广泛关注。在此背景下,本视角论文对不同生物酒精发酵后的下游加工性能提出了一些浅显的学术见解。由于对微生物的毒性作用较强,发酵液中一水脂肪醇的可达到浓度随着链长的增加而降低。具体来说,这里使用的乙醇、异丙醇、异丁醇和己醇的浓度分别为 6.14、5.00、1.61 和 0.24 wt%。发酵液越稀,回收过程越复杂。根据我们之前的研究,总净化成本从乙醇的 0.080 美元 kg-1、异丙醇的 0.109 美元 kg-1 和异丁醇的 0.161 美元 kg-1 增加到己醇的 0.529 美元 kg-1。能耗(分别为 0.960、1.348、2.018 和 3.069 千瓦时/千克-1)和相关的二氧化碳排放量(分别为 0.164、0.221、0.449 和 0.555 千克二氧化碳/千克-1)也呈类似趋势。这项工作表明,基于工艺强化原理的先进分离和提纯技术对于整体高效生产工艺至关重要。发酵液中可达到的产品浓度--而不是酒精链的长度--对下游加工的性能影响最大。因此,要确保工业发酵工艺的竞争力和可行性,就必须同时发展上游和下游工艺。© 2024 作者。化学技术和生物技术期刊》由约翰威利和桑斯有限公司代表化学工业学会(SCI)出版。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

A perspective on downstream processing performance for recovery of bioalcohols

A perspective on downstream processing performance for recovery of bioalcohols

Even though industrial biotechnology is successfully used for the production of some chemicals, for many other chemicals it is not yet competitive with conventional petrochemical production. Usually, fermentation as well as downstream processing requires improvement. Downstream processing has to deal with low product concentrations, microorganisms, impurities and thermodynamic constraints (e.g., azeotropes), which often makes it very challenging and expensive, especially on a large scale. However, downstream processing of biochemicals has not attracted as much attention as upstream fermentation processes. In that context, this perspective paper offers a lightly referenced scholarly opinion about the downstream processing performance of different bioalcohols after fermentation. Due to the stronger toxicity effects on microbes, the achievable concentrations of monohydric aliphatic alcohols in the fermentation broth decrease with the increasing chain length. Specifically, the concentrations used here are 6.14, 5.00, 1.61 and 0.24 wt% of ethanol, isopropanol, isobutanol and hexanol, respectively. More dilute fermentation broths lead to more complex recovery processes. According to our previous work, the total purification costs increase from 0.080 USD kg−1 for ethanol, 0.109 USD kg−1 for isopropanol and 0.161 USD kg−1 for isobutanol to 0.529 USD kg−1 for hexanol. A similar trend is noticeable for the energy usage (0.960, 1.348, 2.018 and 3.069 kWthh kg−1, respectively) and the related CO2 emissions (0.164, 0.221, 0.449 and 0.555 kgCO2 kg−1, respectively). This work shows that advanced separation and purification based on process intensification principles are crucial for overall efficient production processes. The achievable product concentration in the fermentation broth – and not so much the alcohol chain length – has the biggest influence on the performance of downstream processing. Therefore, simultaneous development of both upstream and downstream processing is necessary to ensure the competitiveness and viability of industrial fermentation processes. © 2024 The Author(s). Journal of Chemical Technology and Biotechnology published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry (SCI).

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
7.00
自引率
5.90%
发文量
268
审稿时长
1.7 months
期刊介绍: Journal of Chemical Technology and Biotechnology(JCTB) is an international, inter-disciplinary peer-reviewed journal concerned with the application of scientific discoveries and advancements in chemical and biological technology that aim towards economically and environmentally sustainable industrial processes.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信