神经欺骗：乳腺癌利用神经元机制躲避免疫系统的攻击

IF 48.8 1区医学 Q1 CELL BIOLOGY

Cancer Cell Pub Date : 2024-05-30 DOI:10.1016/j.ccell.2024.05.007

Nikolas Layer, Lukas Bunse, Varun Venkataramani

引用次数: 0

摘要

介导免疫疗法抵抗的细胞机制尚不完全清楚。在本期杂志中，Li 等人揭示了乳腺癌如何劫持神经元的神经保护机制，使自己免受免疫系统的攻击。在神经炎症和乳腺癌模型中，N-乙酰天冬氨酸的分泌都会损害免疫突触的形成，从而为新型治疗方法铺平道路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Neural deception: Breast cancer co-opts neuronal mechanisms to evade the immune system

Cellular mechanisms mediating immunotherapy resistances are incompletely understood. In this issue, Li et al. reveal how breast cancer hijacks neuronal mechanisms of neuroprotection to shield itself from the immune system. Secretion of N-acetylaspartate impairs immune synapse formation in both neuroinflammation and breast cancer models, paving the way for novel therapeutic approaches.

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来源期刊

Cancer Cell 医学-肿瘤学

CiteScore

55.20

自引率

1.20%

发文量

179

审稿时长

4-8 weeks

期刊介绍： Cancer Cell is a journal that focuses on promoting major advances in cancer research and oncology. The primary criteria for considering manuscripts are as follows: Major advances: Manuscripts should provide significant advancements in answering important questions related to naturally occurring cancers. Translational research: The journal welcomes translational research, which involves the application of basic scientific findings to human health and clinical practice. Clinical investigations: Cancer Cell is interested in publishing clinical investigations that contribute to establishing new paradigms in the treatment, diagnosis, or prevention of cancers. Insights into cancer biology: The journal values clinical investigations that provide important insights into cancer biology beyond what has been revealed by preclinical studies. Mechanism-based proof-of-principle studies: Cancer Cell encourages the publication of mechanism-based proof-of-principle clinical studies, which demonstrate the feasibility of a specific therapeutic approach or diagnostic test.