与 COVID-19 相关的潜在精神疾病和严重后果风险。

Angelica Castro, Hong-Yen Vi
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引用次数: 0

摘要

背景:根据美国疾病控制与预防中心(Centers for Disease Control and Prevention)的资料,抑郁症和精神分裂症等疾病会使患者面临严重感染 COVID-19 的高风险。高危患者通常有资格接受门诊治疗,如抗病毒和单克隆抗体治疗,以预防严重感染。然而,在伊利诺伊州北芝加哥的詹姆斯-A-洛弗尔上尉联邦医疗保健中心,抑郁症和精神分裂症并不被视为严重感染 COVID-19 的风险因素,因此患有这些疾病的患者没有资格接受门诊治疗,除非他们患有其他高风险疾病:这项回顾性队列研究评估了轻度至中度 COVID-19 患者的预后,以确定抑郁症和/或精神分裂症是否会影响重症风险或不良预后。主要结果是严重的COVID-19结果,即感染后30天内住院、入住重症监护室、插管或机械通气或死亡:结果:抑郁症或精神分裂症患者的住院和死亡人数较多,但差异无统计学意义(P = .36)。只有抑郁症或精神分裂症患者在感染 COVID-19 后 30 天内死亡:结论:尽管与无抑郁症和精神分裂症的患者相比,抑郁症和精神分裂症患者在感染 COVID-19 后 30 天内住院和死亡的人数更多,但这一结果并无统计学意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Underlying Mental Illness and Risk of Severe Outcomes Associated With COVID-19.

Background: According to the Centers for Disease Control and Prevention, depression and schizophrenia, among other conditions, put individuals at high risk for severe COVID-19 infection. Patients at high risk often are eligible for outpatient therapies, such as antiviral and monoclonal antibody therapies, to prevent severe infection. However, depression and schizophrenia are not considered risk factors for severe COVID-19 infection at the Captain James A. Lovell Federal Health Care Center in North Chicago, Illinois, making patients with these conditions ineligible for outpatient therapy unless they have another high-risk condition.

Methods: This retrospective cohort study assessed outcomes among patients with mild-to-moderate COVID-19 to determine whether depression and/or schizophrenia impacted the risk of severe disease or negative outcomes. The primary outcome was severe COVID-19 outcomes defined as hospitalization, admission to the intensive care unit, intubation or mechanical ventilation, or death within 30 days of infection.

Results: Patients with depression or schizophrenia had more hospitalizations and deaths, but this difference was not statistically significant (P = .36). Death within 30 days of COVID-19 infection only occurred in patients with depression or schizophrenia.

Conclusions: Although there were more hospitalizations and deaths from COVID-19 within 30 days of infection among patients with depression and schizophrenia compared with individuals without these disorders, this finding was not statistically significant.

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